Results 81 to 90 of about 2,510,388 (303)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Platelets in infection: intrinsic roles and functional outcomes

Frontiers in Immunology
Platelets have long been acknowledged for their essential roles in hemostasis and thrombosis; however, recent insights highlight their broader involvement as key participants in host responses during infection. Beyond their classical functions, platelets
Yuwei Hu, Yuwei Hu, Shuchang Dai, Shuchang Dai, Congchao Qiao, Congchao Qiao, Congchao Qiao, Yifan Ye, Junyi Ren, Kai Wang, Kai Wang, Ling Li, Ling Li, Zhong Liu, Zhong Liu   +14 more
doaj   +1 more source

Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015

BMC Pharmacology and Toxicology, 2019
Background This active, open observational study aimed to investigate adverse drug reactions (ADRs) associated with six commonly used antiepileptic drugs (AEDs) in southern Chinese outpatients with epilepsy from 2003 to 2015. Methods The Wenzhou Epilepsy
Yanru Du, Jiahe Lin, Jingzan Shen, Siqi Ding, Mengqian Ye, Li Wang, Yi Wang, Xinshi Wang, Niange Xia, Rongyuan Zheng, Hong Chen, Huiqin Xu   +11 more
doaj   +1 more source

Analysis of Adverse Reactions of Cosmetics in Chinese Han Population in Recent Five Years

, 2023
Canbin Dong,1,* Fang Liu,1,* Zuda Liao,2 Lanmei Lin,1 Runnan Wang,1 Juan Du,1 Wen Huang1 1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai Institute of Dermatology, Shanghai, People’s Republic of China; 2Medical Insurance ...
Liao Z, Wang R, Huang W, Du J, Lin L, Dong C, Liu F   +6 more
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Mining and evaluation of security alert signals of neuroprotective agents based on the Jinan adverse event reporting system database: a retrospective study

Frontiers in Pharmacology
BackgroundPharmacologic agents with proposed neuroprotective properties are increasingly investigated; however, limited regulation and heterogeneous evidence raise concerns about their safety profiles. To establish a foundation for its safe clinical use,
Yu-yao Guan, Jing Yang, Ying-mei Qi, Chao Song, Lei Zheng   +4 more
doaj   +1 more source

Glycopeptide Hypersensitivity and Adverse Reactions

Pharmacy, 2020
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most ...
Vanthida Huang, Nicola A. Clayton, Kimberly H. Welker   +2 more
doaj   +1 more source

A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment. [PDF]

, 2011
BACKGROUND: Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment.
Dhakal, Sushmita, Macdonald Murdo, Kishori Mahat, Walker Stephen L., Deanna A Hagge, Ruchal Shudan, Diana N J Lockwood, Deanna A. Hagge, Nicholls Peter G., Peter G Nicholls, Stephen L. Walker, Ruchal, Shudan, Kapil D. Neupane, Peter G. Nicholls, Neupane, Kapil D, Diana N. J. Lockwood, Lockwood, Diana NJ, Neupane Kapil D., Shudan Ruchal, Walker, Stephen L, Kapil D Neupane, Hagge, Deanna A, Stephen L Walker, Sushmita Dhakal, Hamal Sushma, Hawksworth, Rachel A, Murdo Macdonald, Sushma Hamal, Nicholls, Peter G, Rachel A Hawksworth, Lockwood Diana N. J., Hagge Deanna A., Macdonald, Murdo, Mahat Kishori, Dhakal Sushmita, Hawksworth Rachel A., Mahat, Kishori, Rachel A. Hawksworth, Hamal, Sushma   +38 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source