Results 41 to 50 of about 54,472 (238)
Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source
A thermal neutrino interaction rate at NLO
Nuclear Physics B, 2020 The interaction rate of an ultrarelativistic active neutrino at a temperature below the electroweak crossover plays a role in leptogenesis scenarios based on oscillations between active neutrinos and GeV-scale sterile neutrinos.
G. Jackson, M. Laine
doaj +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
Optimal setting automatic excitation controllers for synchronous generators
Известия высших учебных заведений: Проблемы энергетики, 2017 At present, the power system of the Russian Federation is an active modernization of generator excitation systems. In this connection, there is the problem of choosing the new settings excitation controllers of various types to ensure effective damping ...
R. I. Kanafeev +2 more
doaj +1 more source
A Novel Three-Dimensional Non-Destructive Beam-Monitoring Detector
Applied Sciences, 2020 A novel three-dimensional non-destructive beam monitor named π3 was conceived, realized and tested. It is based on a thin aluminum foil coated with P47 scintillating material mounted on a support, together with a miniaturized CCD camera, both moving ...
Carolina Belver-Aguilar +6 more
doaj +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
On Computer-Assisted Language Learning and the AEC [PDF]
, 2014 In this essay I add to the discussion on CALL, LEO, and technology use at the AEC. I begin with a brief discussion of CALL and LEO and then survey issues and challenges relevant to the broader field of computer-assisted language learning.
Berardo, Marcellino, Marcellino Berardo
core +2 more sources
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Scientific ReportsDiabetic retinopathy (DR), a prevalent microvascular complication of diabetes mellitus (DM), can be prevented with early detection and timely intervention.
Anshul Chauhan +8 more
doaj +1 more source
Advanced Science, EarlyView.Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source