Results 121 to 130 of about 12,489,898 (339)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Rotor blade aerodynamic design [PDF]
Aerodynamic performance aspects of rotor blade design are presented.
Noonan, Kevin W., Walsh, Joanne L.
core +1 more source
Aerodynamic Analysis Of Voice In Persons With Laryngopharyngeal Reflux [PDF]
, 2009 Objectives of the study: The individuals with laryngopharyngeal reflux are prone for aspiration of refluxed contents and so there is a need for aerodynamic evaluation in these individuals.
B, Radish Kumar, Bhat, Jayashree S. Bhat
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimum design of high speed prop rotors including the coupling of performance, aeroelastic stability and structures [PDF]
An optimization procedure is developed for the design of high speed prop-rotors to be used in civil tiltrotor applications. The goal is to couple aerodynamic performance, aeroelastic stability, and structural design requirements inside a closed-loop ...
Chattopadhyay, Aditi +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Optimization and design of three-dimensional aerodynamic configurations of arbitrary shape by a vortex lattice method [PDF]
A new method based on vortex lattice theory has been developed which can be applied to the combined analysis, induced drag optimization, and aerodynamic design of three-dimensional configurations of arbitrary shape.
Feifel, W. M.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The development of aerodynamic uncertainties for the space shuttle orbiter [PDF]
, 1983 The Shuttle Program development schedule and the management decision to perform an orbital, manned mission on the first launch resulted in a requirement to develop realistic aerodynamic uncertainties for the preflight aerodynamic predictions.
Underwood, J. M., Young, J. C.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source