Results 131 to 140 of about 12,489,898 (339)

NASTRAN level 16 user's manual updates for aeroelastic analysis of bladed discs [PDF]

The NASTRAN aeroelastic and flutter capability was extended to solve a class of problems associated with axial flow turbomachines. The capabilities of the program are briefly discussed.
Elchuri, V., Gallo, A. M.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research progress on aerodynamic stealth design technology of aircraft

Hangkong gongcheng jinzhan
Aerodynamic stealth design is a key technology for aircraft to realize efficient combat in high-risk environments，and it has been a hot technology researched by aviation powers for a long time.
ZHAO Ke, GAO Zhenghong, ZHOU Lin, XIA Lu, DENG Jun, HUANG Jiangtao   +5 more
doaj   +1 more source

Applications of CONMIN to wing design optimization with vortex flow effect [PDF]

Slender wings on supersonic cruise configurations are expected to be thin and highly swept. As a result, edge-separated vortex flow is inevitable and must be accounted for in aerodynamic analysis and design.
Lan, C. E.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Study on landing control method based on incremental dynamic inverse

Hangkong gongcheng jinzhan
Accurate landing control and improving the safety and reliability of the landing process are difficult issues in the safe recovery of carrier based aircraft. A landing control system based on incremental dynamic inverse is proposed.
DUAN Zhuoyi, ZHAO Letian, ZHANG Junhong, LIU Xiaoxiong   +3 more
doaj   +1 more source

Computational aerodynamics and design [PDF]

, 1982
The availability of supercomputers and the ingenuity of computational aerodynamics in design, and prospects for continued advancement are assessed.
openaire   +1 more source

Design of 3-dimensional complex airplane configurations with specified pressure distribution via optimization [PDF]

A subcritical panel method applied to flow analysis and aerodynamic design of complex aircraft configurations is presented. The analysis method is based on linearized, compressible, subsonic flow equations and indirect Dirichlet boundary conditions ...
Kubrynski, Krzysztof
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source