Results 51 to 60 of about 68,481 (311)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Research on Efficient Particle Swarm Optimization and Aerodynamic Stealth Integrated Design of Fly-wing UAV

Hangkong gongcheng jinzhan, 2019
To deal with the problem of aerodynamic and stealth integrated optimization of fly-wing UAV, a multi-objective optimization study on aerodynamic and stealth of the fly-wing UAV is carried out which based on the free-form surface deformation(FFD). The FFD
Fan Huayu, Zhan Hao, Cheng Shixin, Mi Baigang, Yao Huiqin   +4 more
doaj   +1 more source

Robust aerodynamic design of variable speed wind turbine rotors [PDF]

, 2012
This study focuses on the robust aerodynamic design of the bladed rotor of small horizontal axis wind turbines. The optimization process also considers the effects of manufacturing and assembly tolerances on the yearly energy production.
Campobasso, Michele Sergio, Minisci, Edmondo, Vasile, Massimiliano   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

An Improved Approach for Reducing the Dimensionality of Wing Aerodynamic Optimization Considering Longitudinal Stability

Aerospace
The wing aerodynamic shape optimization is a typical high-dimensional problem with numerous independent design variables. Researching methods to reduce the dimensionality of optimization from the perspective of aerodynamic characteristics is necessary ...
Boqian Ji, Jun Huang, Xiaoqiang Lu, Yacong Wu, Jingjiang Liu   +4 more
doaj   +1 more source

Study of the development and verification of an integrated code for UAV design [PDF]

, 2015
L'objectiu d'aquest estudi és desenvolupar una eina de disseny d'aeronaus utilitzant algoritmes d'optimització per a facilitar el procés. Es pretén incorporar el codi d'estudi i simulació de les actuacions d'un UAV desenvolupat per l'equip Trencalòs Team
Armengol Garcia, Lluís
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Stealth Unmanned Aerial Vehicle Penetration Efficiency Optimization Based on Radar Detection Probability Model

Aerospace
Aerodynamic/stealth optimization is a key issue during the design of a stealth UAV. Balancing the weight of different incident angles of the RCS and combining stealth characteristics with aerodynamic characteristics are hotspots of aerodynamic/stealth ...
Chengen Yuan, Dongli Ma, Yuhong Jia, Liang Zhang   +3 more
doaj   +1 more source

Application of Nontraditional Optimization Techniques for Airfoil Shape Optimization

Modelling and Simulation in Engineering, 2012
The method of optimization algorithms is one of the most important parameters which will strongly influence the fidelity of the solution during an aerodynamic shape optimization problem.
R. Mukesh, K. Lingadurai, U. Selvakumar
doaj   +1 more source

Optimization of UAV Airfoil Based on Improved Particle Swarm Optimization Algorithm

International Journal of Aerospace Engineering, 2022
Airfoil optimization is an essential task in the aerodynamic layout design of the unmanned aerial vehicle (UAV). An objective optimization function was constructed based on the airfoil power factor and handling stability at various attack angles.
Tieying Jiang, Liang Jiang
doaj   +1 more source