Results 121 to 130 of about 147,005 (295)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Analysis of aerodynamic characteristics of hypersonic folding-wing aircraft
Hangkong gongcheng jinzhanHypersonic aircraft encounter challenges in adapting to complex external environments during missions. Conventional fixed-wing aircraft have limited optimal aerodynamic performance under specific conditions.
WU Zaoping, QIN Jian, WU Jie
doaj +1 more source
Nozzle and wing geometry effects on OTW aerodynamic characteristics [PDF]
The effects of nozzle geometry and wing size on the aerodynamic performance of several 5:1 aspect ratio slot nozzles are presented for over-the-wing (OTW) configurations.
Groesbeck, D., Vonglahn, U.
core +1 more source
Advanced propeller aerodynamic analysis [PDF]
, 1980 The analytical approaches as well as the capabilities of three advanced analyses for predicting propeller aerodynamic performance are presented. It is shown that two of these analyses use a lifting line representation for the propeller blades, and the ...
Bober, L. J.
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Aerobee 150 structural and aerodynamic pitch coupling [PDF]
Aerobee 150 structural and aerodynamic pitch coupling failure analysis based on flight performance data ...
Busse, J. R., Kraft, G. E.
core +1 more source
Robust aerodynamic design of variable speed wind turbine rotors [PDF]
, 2012 This study focuses on the robust aerodynamic design of the bladed rotor of small horizontal axis wind turbines. The optimization process also considers the effects of manufacturing and assembly tolerances on the yearly energy production.
Campobasso, Michele Sergio +2 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source