Results 101 to 110 of about 39,978 (316)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Towards a Balanced Design of a Grid Fin with Lightweight Aerodynamics and Structural Integrity

Aerospace
It is widely accepted that the lightweight design of a grid fin is closely related to its aerodynamic performance and structural integrity, while limited work seeks their balance.
Yuxin Liu, Mingliang Zhu, Fuzhen Xuan
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PrandtlPlane High–Lift System Preliminary Aerodynamic Design

, 2006
An analysis of low-speed aerodynamics for an unconventional aircraft configuration has been carried out. This configuration, named Prandtlplane, implements Prandtl's Best Wing System for low induced drag.
Iezzi, Giuseppe
core  

Interactional aerodynamics and acoustics of a hingeless coaxial helicopter with an auxiliary propeller in forward flight [PDF]

, 2008
The aerodynamics and acoustics of a generic coaxial helicopter with a stiff main rotor system and a tail- mounted propulsor are investigated using Brown's Vorticity Transport Model.
Brown, R.E., Kenyon, A.R., Kim, Hyo Wan, Kenyon, Adam R., Duraisamy, K., Kim, H.W., Duraisamy, Karthikeyan, Brown, Richard   +7 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Mathematical Model to Analyze the Static Stability of Hybrid (Aero- Hydrodynamically Supported) Vehicles. [PDF]

, 2008
Among the new concepts developed for high speed marine vehicles over the last two decades, the "aerodynamic alleviation" approach consists in using an aerodynamic surface to "alleviate" the weight sustained by the hydrodynamic lift.
Patel, Minoo H., Trarieux, Florent, Collu, Maurizio   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The longitudinal static stability of an aerodynamically alleviated marine vehicle, a mathematical model [PDF]

, 2010
An assessment of the relative speeds and payload capacities of airborne and waterborne vehicles highlights a gap that can be usefully filled by a new vehicle concept, utilizing both hydrodynamic and aerodynamic forces.
Patel, Minoo H., Trarieux, Florent, Collu, Maurizio   +2 more
core   +1 more source