Results 81 to 90 of about 147,005 (295)
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Aerodynamic performance of flared fan nozzles used as inlets [PDF]
Tests were conducted in a low speed wind tunnel to determine the aerodynamic performance of several flared fan nozzles. Each of the flared nozzles was a downstream-facing inlet to a model fan that was used to simulate a variable pitch fan during reverse ...
Dietrich, D. A. +2 more
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Towards a Balanced Design of a Grid Fin with Lightweight Aerodynamics and Structural Integrity
AerospaceIt is widely accepted that the lightweight design of a grid fin is closely related to its aerodynamic performance and structural integrity, while limited work seeks their balance.
Yuxin Liu, Mingliang Zhu, Fuzhen Xuan
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The aerodynamic design of an advanced rotor airfoil [PDF]
An advanced rotor airfoil, designed utilizing supercritical airfoil technology and advanced design and analysis methodology is described. The airfoil was designed subject to stringent aerodynamic design criteria for improving the performance over the ...
Blackwell, J. A., Jr., Hinson, B. L.
core +1 more source
Rotor-Obstacle Aerodynamic Interaction in Hovering Flight: An Experimental Survey [PDF]
, 2016 Despite the presence of a fair number of numerical and experimental works on the rotor-obstacle interaction, a systematic study of the aerodynamic phenomena involved is lacking.
Giuni, Michea +2 more
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Aerodynamic performance of scarf inlets [PDF]
A scarf inlet is characterized by having a longer lower lip than upper lip leading to both aerodynamic and acoustic advantages. Aerodynamically, a scarf inlet has higher angle of attack capability and is less likely to ingest foreign objects while the ...
Abbott, J. M.
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source