Results 61 to 70 of about 224,566 (258)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Robust aerodynamic design of variable speed wind turbine rotors [PDF]

, 2012
This study focuses on the robust aerodynamic design of the bladed rotor of small horizontal axis wind turbines. The optimization process also considers the effects of manufacturing and assembly tolerances on the yearly energy production.
Campobasso, Michele Sergio, Minisci, Edmondo, Vasile, Massimiliano   +2 more
core  

Efficient preliminary floating offshore wind turbine design and testing methodologies and application to a concrete spar design [PDF]

, 2015
The current key challenge in the floating offshore wind turbine industry and research is on designing economic floating systems that can compete with fixed-bottom offshore turbines in terms of levelized cost of energy. The preliminary platform design, as
Campos Hortigüela, Alexis, Cheng, Po Wen, Matha, Denis, Molins i Borrell, Climent, Sandner, Frank   +4 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Data Mining-Based Design Space Exploration and Optimization for Tandem Airfoils

International Journal of Aerospace Engineering, 2023
The joined-wing configuration has great technical appeal for the development of next-generation SensorCraft. Research based on the simplified tandem airfoil system can improve understanding of the joined-wing configuration’s aerodynamic characteristics ...
Yayun Shi, Xiayu Lan, Yiwen Wang, Tihao Yang, Yan Liu   +4 more
doaj   +1 more source

Aerodynamic Optimization of High-Speed Trains Nose using a Genetic Algorithm and Artificial Neural Network [PDF]

, 2011
An aerodynamic optimization of the train aerodynamic characteristics in term of front wind action sensitivity is carried out in this paper. In particular, a genetic algorithm (GA) is used to perform a shape optimization study of a high-speed train nose ...
Crespo Martínez, Antonio, García García, Javier, Muñoz Paniagua, Jorge   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Robust Algorithm Software for NACA 4-Digit Airfoil Shape Optimization Using the Adjoint Method

Applied Sciences, 2023
Optimizing the aerodynamic shape of an airfoil is a critical concern in the aviation industry. The introduction of flexible airfoils has allowed the shape of the airfoil to vary, depending on the flight conditions. Therefore, in this study, we propose an
Naser Tanabi, Agesinaldo Matos Silva, Marcosiris Amorim Oliveira Pessoa, Marcos Sales Guerra Tsuzuki   +3 more
doaj   +1 more source

Advances in Aerodynamic Shape Optimization [PDF]

, 2005
The accumulated experience of the last decade suggests that most existing aircraft which cruise at transonic speeds are amenable to a drag reduction of the order of 3 to 5 percent, or an increase in the drag rise Mach number of at least .02. These improvements can be achieved by very small shape modifications, which are too subtle to allow their ...
openaire   +1 more source