Results 71 to 80 of about 224,566 (258)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Rapid design method of rocket aerodynamic shape based on conditional diffusion model
Kongqi donglixue xuebaoAerodynamic design plays a vital role in rocket design. To expedite the design process of rocket aerodynamic shapes and minimize tedious iterative optimization, this study proposes a generative rapid inverse design method for rocket aerodynamic shapes ...
Chuan Li +5 more
doaj +1 more source
Adjoint Optimization Method for Head Shape of High- Speed Maglev Train
Journal of Applied Fluid Mechanics, 2021 The head shape of a high-speed maglev train was optimized in this study, based on the adjoint method, and the aerodynamic drag of four optimized train models were simulated and compared using different control point generation methods.
H. C. Li, Z. M. Yang, L. Zhang, R. Li
doaj
Chinese Journal of Aeronautics, 2020 A variable-fidelity method can remarkably improve the efficiency of a design optimization based on a high-fidelity and expensive numerical simulation, with assistance of lower-fidelity and cheaper simulation(s).
Zhonghua Han +5 more
semanticscholar +1 more source
Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications [PDF]
Fundamental equations of aerodynamic sensitivity analysis and approximate analysis for the two dimensional thin layer Navier-Stokes equations are reviewed, and special boundary condition considerations necessary to apply these equations to isolated ...
Hou, Gene W., Taylor, Arthur C., III
core +4 more sources
Aerodynamic Design and Shape Optimization with the Far-Field Drag Decomposition Approach
Xibei Gongye Daxue Xuebao, 2020 In the aerodynamic shape design, the drag prediction has always been an extremely challenging mission for the exploration of a configuration. As for the more complex configurations, it is especially desired to the availability of a highly accurate and ...
doaj +1 more source
Coupled CFD Shape Optimization for aerodynamic profiles [PDF]
, 2016 The present document deals with the optimization of shape of aerodynamic profiles -- The objective is to reduce the drag coefficient on a given profile without penalising the lift coefficient -- A set of control points defining the geometry are passed ...
Giraldo Arias, Santiago
core
, 2021 In this paper, a computationally efficient multifidelity local search algorithm for aerodynamic design optimization is presented.
J. Nagawkar +4 more
semanticscholar +1 more source
Adjoint-based aerodynamic shape optimization including transition to turbulence effects
Aerospace Science and Technology, 2020 The inclusion of transition to turbulence effects in aerodynamic shape optimization makes it possible to use it as a tool for the design of airframes with laminar flow.
G. L. Halila, J. Martins, K. Fidkowski
semanticscholar +1 more source
Three-Dimensional Large-Scale Aerodynamic Shape Optimization Based on Shape Calculus [PDF]
AIAA Journal, 2011 Large-scale three-dimensional aerodynamic shape optimization based on the compressible Euler equations is considered. Shape calculus is used to derive an exact surface formulation of the gradients, enabling the computation of shape gradient information for each surface mesh node without having to calculate further mesh sensitivities.
Schmidt, Stephan +3 more
openaire +3 more sources