Results 61 to 70 of about 131,365 (295)

Assessment of a Mid-Fidelity Numerical Approach for the Investigation of Tiltrotor Aerodynamics [PDF]

, 2021
Alex Zanotti, Alberto Savino, Michele Palazzi, Matteo Tugnoli, Vincenzo Muscarello   +4 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Influence of Double-Ducted Serpentine Nozzle Configurations on the Interaction Characteristics between the External and Nozzle Flow of Aircraft

Aerospace
To clarify the influence of the serpentine nozzle configurations on the flow characteristics and aerodynamic performance of aircraft, the flow features and aerodynamic performances of the double-ducted serpentine nozzles with different aspect ratios (AR),
Jilong Zhu, Yi Zhang, Yaohua Li, Liquan Zeng, Lei Miao, Neng Xiong, Yang Tao   +6 more
doaj   +1 more source

Simulating the aerodynamic performance and wake dynamics of a vertical-axis wind turbine [PDF]

, 2011
The accurate prediction of the aerodynamics and performance of vertical-axis wind turbines is essential if their design is to be improved but poses a signifi cant challenge to numerical simulation tools.
Brown, Richard, Fletcher, Timothy M., Scheurich, Frank   +2 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

A Viscous Boundary Layer Mesh Adaptation Method and Its Application in High-Angle-of-Attack Separated Flows

Applied Sciences
Adjoint-based mesh adaptation method serves as an effective approach to improve the predictive accuracy of aerodynamic characteristics. However, viscous boundary layer grids often encounter issues such as hanging nodes, negative volumes, and directional ...
Pengcheng Cui, Xiaojun Wu, Jiangtao Chen, Hongyin Jia, Fan Qin, Jie Zhang, Yaobing Zhang, Guiyu Zhou, Jing Tang   +8 more
doaj   +1 more source

Transonic Static Aeroelastic Numerical Analysis of Flexible Complex Configuration Wing

Shock and Vibration, 2021
Diamond back wing is subjected to large deformation while gliding, which significantly changes characteristics of the lift as well as the static stability.
Changrong Zhang, Hongtao Guo, Binbin Lv, Jun Zha, Li Yu   +4 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

An experimental investigation of the aerodynamics and cooling of a horizontally-opposed air-cooled aircraft engine installation [PDF]

A flight-test based research program was performed to investigate the aerodynamics and cooling of a horizontally-opposed engine installation. Specific areas investigated were the internal aerodynamics and cooling mechanics of the installation, inlet ...
Cross, E. J., Jr., Lawrence, D. L., Miley, S. J., Owens, J. K.   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source