Results 41 to 50 of about 1,139 (252)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Adaptive Turbulence Model for Leading Edge Vortex Flows Preconditioned by a Hybrid Neural Network
AerospaceEddy-viscosity-based turbulence models provide the most commonly used modeling approach for computational fluid dynamics simulations in the aerospace industry.
Moritz Zieher, Christian Breitsamter
doaj +1 more source
Aerospace, 2017 This work presents numerical and experimental investigations of an elasto-flexible membrane wing at a Reynolds number of 280,000. Such a concept has the capacity to adapt itself to the incoming flow offering a wider range of the flight envelope.
Julie Piquee, Christian Breitsamter
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
PRELIMINARY CALCULATIONS OF FLOW IN CHANNEL WITH TRIANGULAR AND RECTANGULAR OBSTACLE
TASK Quarterly, 2010 The paper presents the results of preliminary numerical calculations of a fluid flow in a channel with an obstacle. The flow problem was solved with an application of the finite elements method. Various geometries of obstacles were considered.
MAŁGORZATA KMIOTEK, ANNA KUCABA-PIĘTAL
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
International Journal of Aviation, Aeronautics, and Aerospace, 2020 It is very essential to predict the flow and its related parameters to understand real life fluid flow. The real-life fluid problems are studied with wind tunnels which gives very efficient results in practice. But in the case of wind tunnel studies flow
Akhila Rupesh, J V Muruga Lal Jeyan
doaj +1 more source