Results 51 to 60 of about 1,139 (252)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Wind Tunnel Investigation of Transient Propeller Loads for Non-Axial Inflow Conditions

Aerospace
Recent developments in electrical Vertical Take-off and Landing (eVTOL) vehicles show the need for a better understanding of transient aero-mechanical propeller loads for non-axial inflow conditions.
Catharina Moreira, Nikolai Herzog, Christian Breitsamter   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Investigating cell viability under shear stress in complex microstreaming flows generated by ultrasound-driven actuated microbubbles

Flow
In this study, we introduce a method, applied for the first time to manipulate human cells, by leveraging the controlled activation and deactivation of microbubble streaming – previously used for rigid polymer particles. This innovative technique enables
Amirabas Bakhtiari, Benedikt Schumm, Martin Schönfelder, Christian J. Kähler   +3 more
doaj   +1 more source

Impact of a Reverse Delta Type Add-on Device on the Flap-tip Vortex of a Wing

International Journal of Aviation, Aeronautics, and Aerospace, 2016
The effect of interactions of vortices produced by an outboard flap-tip of a half-span wing (NACA 23012 in landing configuration) and a slender reverse delta type add-on device, placed in the proximity of the outboard flap-tip, on the upper surface of ...
Afaq Altaf, Tan Boon Thong, Ashraf Ali Omar, Waqar Asrar   +3 more
doaj   +1 more source

The Detrimental Effect of Rainfall on Performance and Stability Characteristics of Aircrafts-A Comprehensive Review

International Journal of Aviation, Aeronautics, and Aerospace, 2020
The rapidly growing global market demands faster transit of human beings and goods even in unfavorable weather conditions of rainfall. The paper gives an overview of rain research methodologies, mathematical models to track raindrops in the flow field ...
Praneeth HR, Amit Kumar Thakur
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Aerodynamic Optimization of Box Wing – A Case Study

International Journal of Aviation, Aeronautics, and Aerospace, 2014
The optimization of a possible medium range box wing commercial airliner is presented in three stages. Preliminary research is used to determine various parameters for a potential box wing model, and a baseline model is designed in Autodesk Inventor ...
Adeel Khalid, Parth Kumar
doaj   +1 more source