Results 61 to 70 of about 2,332 (298)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Adaptive Turbulence Model for Leading Edge Vortex Flows Preconditioned by a Hybrid Neural Network

Aerospace
Eddy-viscosity-based turbulence models provide the most commonly used modeling approach for computational fluid dynamics simulations in the aerospace industry.
Moritz Zieher, Christian Breitsamter
doaj   +1 more source

Numerical study of a Flexible Sail Plan submitted to pitching : Hysteresis phenomenon and effect of rig Adjustments [PDF]

, 2014
Yacht sails dynamic fluid structure interaction is simulated in harmonic pitching Aerodynamic forces show hysteresis associated to energy dissipation Dissipated energy increases with pitching frequency and amplitude Hysteresis is cancelled and forces ...
AUGIER, Benoit, BOT, Patrick, DURAND, Mathieu, AUBIN, Nicolas, HAUVILLE, Frederic   +4 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Large-scale flow field and aerosol particle transport investigations in a classroom using 2D-Shake-The-Box Lagrangian Particle Tracking

Heliyon, 2023
Infections with COVID-19 in enclosed public spaces, where virus-laden aerosol particles can accumulate over time, have significantly contributed to the rapid spread of the virus.
Tom Buchwald, Gazi Hasanuzzaman, Sebastian Merbold, Daniel Schanz, Christoph Egbers, Andreas Schröder   +5 more
doaj   +1 more source

Assessing the impact of aerodynamic modelling on manoeuvring aircraft

, 2014
This paper investigates the impact of aerodynamic models on the dynamic response of a free-flying aircraft wing. Several options for the aerodynamics are evaluated, from two-dimensional thin aerofoil aerodynamics and unsteady vortex-lattice method up to ...
Hesse, H., Palacios, Rafael, Hesse, H, Da Ronch, Andrea, Palacios, R., Da Ronch, A., Palacios, R, McCracken, AJ, McCracken, Andrew J., Tantaroudas, N.D., Tantaroudas, ND, Badcock, Kenneth J., Da Ronch, A, Badcock, KJ, Hesse, Henrik, Badcock, K.J., McCracken, A.J.   +16 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PRELIMINARY CALCULATIONS OF FLOW IN CHANNEL WITH TRIANGULAR AND RECTANGULAR OBSTACLE

TASK Quarterly, 2010
The paper presents the results of preliminary numerical calculations of a fluid flow in a channel with an obstacle. The flow problem was solved with an application of the finite elements method. Various geometries of obstacles were considered.
MAŁGORZATA KMIOTEK, ANNA KUCABA-PIĘTAL
doaj  

Application of computational fluid dynamics to turbo machinery unsteady aerodynamics and aero acoustics [PDF]

, 2008
The aim of this thesis is to obtain numerical data for fan tone noise propagation and reducing the load from blade-tower interaction. By using a CFD code, MB3D, which is supplied by Professor Li He, fan tone noise transmission and wind turbine blade ...
Dong, Ying
core