Results 121 to 130 of about 12,945,328 (314)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effects of a mindfulness-based health promotion program on mindfulness, psychological capital, compassion fatigue, and affect in healthcare workers

Frontiers in Psychology
ObjectiveThis study aimed to examine the effects of the Mindfulness-Based Health Promotion program on mindfulness, psychological capital, compassion fatigue, and affect in a sample of healthcare workers at a hospital in Colombia.MethodRandomized ...
Eliana Quiroz-González, María Laura Lupano Perugini, María Laura Lupano Perugini, María Laura Lupano Perugini, Leonor Emilia Delgado-Abella, Jaime Arenas-Granada, Marcelo Demarzo   +6 more
doaj   +1 more source

Unaffected Strangers Affect Contributions [PDF]

Several recent experimental studies have confirmed that social sanctioning can enforce cooperation in public good situations. These studies consider situations where the participants, who have monetary interest in the outcome of the public good game ...
Kjetil Telle, Mari Rege
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

How the Charge Can Affect the Formation of Gravastars

, 2010
In recent work we physically interpreted a special gravastar solution characterized by a zero Schwarzschild mass. In fact, in that case, none gravastar was formed and the shell expanded, leaving behind a de Sitter or a Minkowski spacetime, or collapsed ...
, , A.E. Broderick, A.Z. Wang, B.M.N. Carter, C. Cattoen, C. Cattoen, D. Horvat, D. Horvat, F.S.N. Lobo, M. Visser, M.F.A. da Silva, P. Marecki, P. Rocha, P. Rocha, P.O. Mazur, R Chan, R. Adler, R. Chan, R. Chan, R. Chan, T. Faber   +21 more
core   +1 more source

INAPPROPRIATE AFFECT [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1956
A, HARRIS, M, METCALFE
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sticky Categories and Their Negative Consequences: People with Learning Disabilities and ‘Behaviours that Challenge Others’

Scandinavian Journal of Disability Research
‘Behaviours that challenge others’ are attributed to 20% of people with learning disabilities. These behaviours are not a diagnosis, it is something people are labelled with.
Magdalena Mikulak, Sara Ryan, Elizabeth Tilley, Susan Ledger, Lisa Davidson, Pam Bebbigton, Dawn Wiltshire   +6 more
doaj   +1 more source

How institutions affect retailers' internationalization ? [PDF]

This paper examines the institutional and economic factors determining success and failure of global retailers abroad through the trajectories of Wal-Mart and Carrefour.
Cédric Durand
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source