Results 151 to 160 of about 533,233 (349)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5

Virulence
HIV-1 infection activates microglia and triggers neuroinflammation, which is the primary cause of HIV-associated neurological complications. Our previous study demonstrated that HIV-1 infection upregulates m6A modification in microglia, and in this study,
Qian Peng, Weiling Li, Feng Qian, YinYing Zhu, Song Hu, Yingying Shi, Yiyuan Xia, Wei Liu, Xiji Shu, Pin Wan, Yuchen Liu, Binlian Sun   +11 more
doaj   +1 more source

GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders [PDF]

Hannah Hughes, Lillian J. Brady, Kirsten E. Schoonover   +2 more
openalex   +1 more source

A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly

, 2020
Michela Di Nottia, Maria Marchese, Daniela Verrigni, Christian D. Mutti, Alessandra Torraco, Romina Oliva, Erika Fernández‐Vizarra, Federica Morani, Giulia Trani, Teresa Rizza, Daniele Ghezzi, Anna Ardissone, Claudia Nesti, Gessica Vasco, Massimo Zeviani, Michal Minczuk, Enrico Bertini, Filippo M. Santorelli, Rosalba Carrozzo   +18 more
openalex   +1 more source

Cardiovascular comorbidities in hospitalized psychiatric patients with diagnoses of schizophrenic and affective disorders [PDF]

, 2016
Katarina Djokic-Pjescic, Jasmina Gutovic, Jelica Tesic, Aleksandar Djukić, Igor Grbić, Jovana Cvetković   +5 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Maternal Interaction Style in Affective Disordered, Physically Ill, and Normal Women

, 1993
Affective style (AS) and communication deviance (CD) have been suggested as markers of dysfunctional family environments that may be associated with psychiatric illness. Studies have focused mainly on parental responses during family interactions when an
Hamilton, Elizabeth Burney, Hammen, Constance, Jones, Maren   +2 more
core  

The Recent History of Seasonal Affective Disorder (SAD) [PDF]

, 2014
Seminar TranscriptPsychiatric diagnosis is controversial and is regarded by some principally as a means of reinforcing the vested interests of medical professionals and pharmaceutical companies.
Overy, C, Tansey, EM
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review [PDF]

, 1998
Michael E. Newman, Baruch Shapira, Bernard Lerer   +2 more
openalex   +1 more source