Results 191 to 200 of about 9,586 (227)

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Mood Temperaments in Patients With Diabetes Mellitus. [PDF]

Health Sci Rep
Almasi MH, Heidarialmasi T, Delkash P, Shahrbabak HM, Ariana S, Vaziri-Harami R.   +5 more
europepmc   +1 more source

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Dominant depressive temperament and psychological resilience in obsessive-compulsive disorder. [PDF]

BMC Psychiatry
Demirkan AK, Aydin Sunbul E, Cengiz Cavusoglu E, Metin M.   +3 more
europepmc   +1 more source

Conscious and Resilient? Associations Between Temperament, Emotional Awareness, and Emotion Regulation Strategies in Youth. [PDF]

Psychol Belg
Struyf S, Koster EHW, Van Beveren ML, Braet C.   +3 more
europepmc   +1 more source

Affective Temperaments and Seasonality in Patients with Mood Disorders. [PDF]

Neuropsychiatr Dis Treat
Di Vincenzo M, Della Rocca B, Sampogna G, Toni C, Di Cerbo A, Calamaro S, Guida F, Atti AR, Tempia Valenta S, Sani G, Luciano M, Fiorillo A.   +11 more
europepmc   +1 more source

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Altered Affective Temperaments in Women With Vaginismus

The Primary Care Companion For CNS Disorders, 2021
Vaginismus is one of the most frequently occurring genito-pelvic pain disorders in women. Sexual dysfunction commonly presents with comorbid psychiatric disorders, and many patients suffering from the former exhibit the latter. The objective of this study was to investigate the affective temperaments of women with vaginismus compared to healthy ...
Erson, Aksu, Elmas, Beyazyüz, Yakup, Albayrak, Nihan, Potas, Gökçen, Kumandaş, İdil, Bağ, Murat, Beyazyüz   +6 more
openaire   +2 more sources