Results 41 to 50 of about 461,814 (281)
Probing the protein–nanoparticle interface: the role of aromatic substitution pattern on affinity [PDF]
Supramolecular Chemistry, 2014 A new class of cationic gold nanoparticles (NPs) has been synthesised bearing benzyl moieties featuring –NO2 and –OMe groups to investigate the regioisomeric control of aromatic NP–protein recognition. In general, NPs bearing electron-withdrawing groups demonstrated higher binding affinities towards green fluorescent protein (GFP) than NPs bearing ...
Ekmekci, Zeynep +6 more
openaire +4 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
NGMV control of delayed piecewise affine systems [PDF]
, 2010 A Nonlinear Generalized Minimum Variance (NGMV) control algorithm is introduced for the control of piecewise affine (PWA) systems. Under some conditions, discrete-time PWA systems can be transferred into an equivalent state-dependent nonlinear system ...
Pang, Y., Grimble, Michael
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
On extended structures in affine Toda field theory [PDF]
, 1996 Two areas of affine Toda field theory are explored in this thesis. First the introduction of a boundary into the real coupling affine Toda field theory.
Harder, Ulrich Karl Priedrich
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Affine toda field theories on a half-line [PDF]
, 1999 This thesis is primarily concerned with the reflection factors of affine Toda field theories on the half-line x ≤ 0. First, we consider the classical background configurations of low rank a,(^(1)) affine Toda theories with a boundary, constructed by the ...
Perkins, Michael Gordon, Perkins, M.G.
core