Results 81 to 90 of about 469,935 (276)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Affinities of Affectivity

Media Theory
The smartphone is still the reigning fetish of everyday communication. In fact, it has become the fulcrum of all interactive agencies in daily life.
Raymond L. M. Lee
doaj   +1 more source

Electron affinities of the first- and second- row atoms: benchmark ab initio and density functional calculations

, 1999
A benchmark ab initio and density functional (DFT) study has been carried out on the electron affinities of the first- and second-row atoms. The ab initio study involves basis sets of $spdfgh$ and $spdfghi$ quality, extrapolations to the 1-particle basis
A. D. Becke, A. D. Becke, A. D. Becke, A. Halkier, A. Zunger, B. A. Heß, C. Adamo, C. Adamo, C. Adamo, C. Froese Fischer, C. Guo-xin, C. Heinemann, C. Lee, C. Schwartz, C. W. Bauschlicher, Jr., C. W. Bauschlicher, Jr., C. W. Greeff, D. Calabrese, D. E. Woon, D. Feller, D. Feller, D. J. Lacks, D. L. Strout, D. M. Ceperley, D. Sundholm, E. Eliav, F. de Proft, Frank de Proft, G. D. Purvis III, G. L. Gutsev, G. S. Tschumper, G. S. Tschumper, Glênisson de Oliveira, H. B. Shore, J. C. Slater, J. Chen, J. D. Watts, J. J. Novoa, J. M. Galbraith, J. M. García de la Vega, J. M. L. Martin, J. M. L. Martin, J. M. L. Martin, J. Noga, J. Noga, J. P. Perdew, J. P. Perdew, J. P. Perdew, J. P. Perdew, J. P. Perdew, J. Thogersen, J. W. Moskowitz, Jan M. L. Martin, K. Raghavachari, K. Raghavachari, K. Schwarz, K. Schwarz, L. A. Curtiss, L. A. Curtiss, L. A. Curtiss, M. J. Frisch, M. J. Frisch, M. R. Pederson, M. Scheer, M. Scheer, N. Rösch, P. J. Knowles, P. J. Stephens, P. M. W. Gill, P. M. W. Gill, Paul Geerlings, R. A. Kendall, R. A. King, R. A. King, R. Colle, R. D. Adamson, R. D. Cowan, R. G. Parr, R. J. Gdanitz, R. J. Gdanitz, R. J. Gdanitz, R. L. Martin, R. M. Dreizler, S. Goedecker, S. H. Vosko, S. R. Hughes, T. Grabo, T. H. Dunning, Jr., T. J. Van Huis, T. Koga, T. Noro, T. Yoshida, W. Kohn, W. Kohn, W. Kutzelnigg, W. Kutzelnigg, W. P. Wijesundera, W. P. Wijesundera   +97 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

WITTGENSTEIN AND BUDDHISM? ON ALLEGED AFFINITIES WITH ZEN AND MADHYAMAKA [PDF]

, 2015
: Buddhism is popular nowadays and so it becomes in analytic philosophy, as an increasing number of publications on possible intersections between analytic philosophy and Buddhism suggests.
DEMONT-BIAGGI, Florian
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Validação computacional de métodos compostos no estudo de propriedades moleculares

Química Nova, 2011
Composite methods using ONIOM and different basis sets have been used to calculate proton and electron affinities for a set of alcohols at QCISD(T)/6-311++G(2df,p) level of theory.
Gabriel Heerdt, Nelson H. Morgon
doaj   +1 more source