The relationship between primary polymer structure and pattern quality in the directed self‐assembly of chemically modified polystyrene‐block‐poly(methyl methacrylate) derivatives is explored. The perpendicular lamellae are aligned, with a periodicity below 20 nm. No parallel orientations or dislocations form, and line patterns are well defined over an
Shinsuke Maekawa+8 more
wiley +1 more source
The refolding of recombinant human liver methylmalonyl-CoA mutase from inclusion bodies produced in Escherichia coli : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
Human methylmalonyl-CoA mutase (hMCM) is an adenosylcobalamin-dependent enzyme that catalyses the structural rearrangement of (R)-methylmalonyl-CoA to succinyl-CoA as pan of the catabolism of the branched chain amino acids valine, leucine and isoleucine,
Hayes, Michelle Marie
core
Polar Pore Surface of Polyamide Membranes Enabling Efficient Solvent Mixture Separation
A polyamide membrane with polar pore surfaces and relatively large pore is fabricated through interfacial polymerization between polyethyleneimine and trimesoyl chloride. Rapid separation of solvents with polarity differences is achieved by the synergistic effects of pore polarity and size sieving.
Aiwen Zhang+10 more
wiley +1 more source
Successive aqueous (10 ºC, 25 ºC and 80 ºC) and alkaline (1M NaOH; 25 ºC) extractions of milled Parkinsonia aculeata endosperms gave rise to four galactomannan fractions. These extractions furnished viscous galactomannans with Man:Gal ratios ranging from
Ivone Garros-Rosa+4 more
doaj +1 more source
Interfacial Interaction‐Mediated Regulation of Metal Oxidation States for Enhanced CO2 Reduction
A hybrid strategy is employed to optimize bismuth–oxygen interactions, precisely regulating interfacial bismuth–oxygen bonds during topochemical synthesis. This leads to vanadium oxynitride‐bismuth catalyst exhibiting high Faradaic efficiency and durability for formate production, attributed to enhanced reaction thermodynamics and kinetics.
Zhongyuan Ma+6 more
wiley +1 more source
Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,+8 more
core +2 more sources
Solid-Supported Proteins in the Liquid Chromatography Domain to Probe Ligand-Target Interactions
Ligand-target interactions play a central role in drug discovery processes because these interactions are crucial in biological systems. Small molecules-proteins interactions can regulate and modulate protein function and activity through conformational ...
Marcela Cristina de Moraes+2 more
doaj +1 more source
Mitogen-activated protein kinase (MPK) cascades are important for eukaryotic signal transduction. They convert extracellular stimuli (e.g. some hormones, growth factors, cytokines, microbe- or damage-associated molecular patterns) into intracellular ...
W. Hoehenwarter+7 more
semanticscholar +1 more source
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang+9 more
wiley +1 more source
A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants [PDF]
RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge.
Ahmed, Syed Feroj+8 more
core +2 more sources