Results 151 to 160 of about 158,250 (254)

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope. [PDF]

Cell Rep
Rao VN, Sapse IA, Cohn H, Yoo DK, Tong P, Clark JJ, Bozarth B, Chen Y, Srivastava K, Singh G, Krammer F, Simon V, Wesemann DR, Bajic G, Coelho CH.   +14 more
europepmc   +1 more source

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization. [PDF]

Nucleic Acids Res, 2022
Jeong SL, Zhang H, Yamaki S, Yang C, McKemy DD, Lieber MR, Pham P, Goodman MF.   +7 more
europepmc   +1 more source

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

Atomically Dispersed Ni Site Catalysts Accelerating Sluggish Sulfur Redox Kinetics in Nonaqueous Zn‐S Batteries

Advanced Functional Materials, EarlyView.
An atomically dispersed Ni catalyst featuring Ni‐N4 coordination is developed as a sulfur host for nonaqueous Zn─S batteries. This configuration modulates the electronic structure to lower activation barriers during rate‐limiting steps and promotes a robust ZnF2‐rich cathode‐electrolyte interphase, thereby accelerating sulfur redox kinetics ...
Junhyuk Ji, Dongwoo Kim, Nuri Moon, Daehwan Kim, Keon Kim, Nahyung Kim, Young Yong Kim, Won Bae Kim   +7 more
wiley   +1 more source

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation. [PDF]

Science
MacLean AJ, Deimel LP, Zhou P, ElTanbouly MA, Merkenschlager J, Ramos V, Santos GS, Hägglöf T, Mayer CT, Hernandez B, Gazumyan A, Nussenzweig MC.   +11 more
europepmc   +1 more source

Charge‐Tunable Coacervate Micelles for Separator Engineering in Lithium‐Sulfur Batteries

Advanced Functional Materials, EarlyView.
A separator engineering strategy based on charge‐tunable complex coacervate core micelles (C3Ms) is presented to form an ion‐selective layer regulating polysulfide transport in Li–S batteries. The micelles enable uniform adsorption onto commercial polypropylene separators and infiltration throughout the internal pore network, suppressing polysulfide ...
Yongsheng Zhang, J. R. Andrade Aguirre, Julien Es Sayed, Chongyang Jiang, Yuxuan Zhang, Xiaolong He, Yinyu Xiang, Yutao Pei, Xiangping Zhang, Petra Ruldolf, Marleen Kamperman, Giuseppe Portale   +11 more
wiley   +1 more source

In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor. [PDF]

Nat Biomed Eng
Pan A, Bailey CC, Ou T, Xu J, Aristotelous T, Liu X, Hu B, Crynen G, Skamangas N, Bronkema N, Tran MH, Mou H, Zhang X, Alpert MD, Yin Y, Farzan M, He W.   +16 more
europepmc   +1 more source

Pretrainable Geometric Graph Neural Network for Antibody Affinity Maturation

, 2023
Cai H, Zhang Z, Wang M, Zhong B, Li Q, Zhong Y, Wu Y, Ying T, Tang J.   +8 more
europepmc   +1 more source

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

Optimization of synthetic human V_H affinity and solubility through in vitro affinity maturation and minimal camelization. [PDF]

Protein Sci
Bélanger K, Wu C, Sulea T, van Faassen H, Callaghan D, Aubry A, Sasseville M, Hussack G, Tanha J.   +8 more
europepmc   +1 more source