Results 171 to 180 of about 158,250 (254)

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies. [PDF]

Nat Biomed Eng
Yin Y, Guo Y, Jiang Y, Quinlan B, Peng H, Crynen G, He W, Zhang L, Ou T, Bailey CC, Farzan M.   +10 more
europepmc   +1 more source

A Naphthalimide‐Based NIR‐Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis‐Mediated Antitumor Therapy and Broad‐Spectrum Bacterial Inactivation With Rapid Wound Healing

Advanced Healthcare Materials, EarlyView.
An ionic naphthalimide AIE photosensitizer (PS), TPAPV‐NIM‐M, anchors to cellular and bacterial membranes, emits in the far‐red/near‐infrared (NIR) region, and efficiently generates reactive oxygen species (ROS) under white light. Its membrane‐localized photodynamic action drives apoptosis/ferroptosis‐mediated tumor suppression and broad‐spectrum ...
Sayed Mir Sayed, Zeeshan Tahir, Fahri Alkan, Yavuz Nuri Ertas   +3 more
wiley   +1 more source

<i>In silico</i> and <i>in vitro</i> characterisation and affinity maturation of human red blood cell binding aptamers. [PDF]

RSC Adv
Costanzo H, Gooch J, Frascione N.
europepmc   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Affinity maturation of antibody fragments

, 2023
Liu, Jiaqi, Kang, Guangbo, Wang, Jiewen, Yuan, Haibin, Wu, Yili, Meng, Shuxian, Wang, Ping, Zhang, Miao, Wang, Yuli, Feng, Yuanhang, Huang, He, De Marco, Ario   +11 more
openaire   +1 more source

Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies. [PDF]

Proc Natl Acad Sci U S A
Mazigi O, Langley DB, Henry JY, Burnett DL, Sobti M, Walker GJ, Rouet R, Balachandran H, Lenthall H, Jackson J, Ubiparipovic S, Schofield P, Brown SHJ, Schulz SR, Hoffmann M, Pöhlmann S, Post J, Martinello M, Ahlenstiel G, Kelleher A, Rawlinson WD, Turville SG, Bull RA, Stewart AG, Jäck HM, Goodnow CC, Christ D.   +26 more
europepmc   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Development of a new affinity maturation protocol for the construction of an internalizing anti-nucleolin antibody library. [PDF]

Sci Rep
Ribeiro R, Moreira JN, Goncalves J.
europepmc   +1 more source