Results 211 to 220 of about 158,250 (254)
Some of the next articles are maybe not open access.
Journal of Molecular Recognition, 1998
Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity.
J J, VanAntwerp, K D, Wittrup
openaire +2 more sources
Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity.
J J, VanAntwerp, K D, Wittrup
openaire +2 more sources
Antibody affinity maturation in selectively bred high and low‐affinity mice
European Journal of Immunology, 1986AbstractThe affinity of serum antibodies produced by selectively bred lines of mice [high affinity, low affinity, low nonmaturing (N/M)] injected with T‐dependent [human serum albumin (HSA), dinitrophenylated bovine γ‐globulin (DNP‐BGG)] and T‐independent (DNP‐Ficoll) antigens in saline and adjuvant has been determined.
M W, Steward, C, Stanley, M D, Furlong
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Affinity maturation of phage antibodies
2004Abstract Phage display can be used to increase the affinity of antibodies more than a 1000-fold (1, 2). The starting point is typically a specific antibody isolated from a phage antibody library (see Chapter 13). To accomplish affinity maturation (increased affinity) the sequence of the antibody is diversified, the mutant gene repertoire
Ulrik B Nielsen, James D Marks
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Affinity maturation of antibodies assisted by in silico modeling
Proceedings of the National Academy of Sciences of the United States of America, 2008Peter Timmerman +2 more
exaly
Affinity maturation and hypermutation in a simulation of the humoral immune response
European Journal of Immunology, 1996F Celada
exaly