Results 141 to 150 of about 329,197 (260)

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Advancing Kir4.2 Channel Ligand Identification through Collision-Induced Affinity Selection Mass Spectrometry. [PDF]

ACS Chem Biol
Gu Y, Liu M, Ma L, Quinn RJ.
europepmc   +1 more source

Hierarchical Primary‐Secondary Coordination Synchronizes Ion Flux and Sulfur Redox in Solid Polymer Electrolytes

Advanced Functional Materials, EarlyView.
Hierarchical coordination engineering redistributes Li+ from anion‐dominated pairing toward polymer‐mediated binding. Strong primary sites promote salt dissociation, while distributed secondary sites sustain dynamic hopping pathways. This coordination landscape couples ion flux with polysulfide conversion, suppresses transport‐conversion decoupling ...
Zhong‐Wei Zheng, Jing‐Yu Li, Meng‐Che Tsai, Tsung‐I. Yeh, Wei‐Ming Huang, Mohamed Gamal Mohamed, Shiao‐Wei Kuo, Bing‐Joe Hwang, Yun‐Sheng Ye   +8 more
wiley   +1 more source

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL. [PDF]

Front Pharmacol
Sanchez J, Claus C, McIntyre C, Tanos T, Boehnke A, Friberg LE, Jönsson S, Frances N.   +7 more
europepmc   +1 more source

Mechanistic Control of C─H Bond Activation and C─C Coupling in Light‐Driven Methane Conversion to C2+ Products over Multifunctional Photocatalysts

Advanced Functional Materials, EarlyView.
Methane photocatalytic activation under mild conditions remains a formidable challenge in the synthesis of solar fuels. In this review, we emphasize the growing importance of multifunctional materials and hybrid systems within a unified mechanistic framework that integrates selective C─H bond activation, formation and control of intermediates, C─C ...
Di Hu, Yuheng Jiang, Vitaly V. Ordomsky, Bastian Mei, Zhiyong Tang, Andrei Y. Khodakov   +5 more
wiley   +1 more source

Microfluidic Affinity Selection of B-Lineage Cells from Peripheral Blood for Minimal Residual Disease Monitoring in Pediatric B-Type Acute Lymphoblastic Leukemia Patients. [PDF]

Int J Mol Sci
Witek MA, Larkey NE, Bartakova A, Hupert ML, Mog S, Cronin JK, Vun J, August KJ, Soper SA.   +8 more
europepmc   +1 more source

Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor. [PDF]

ACS Chem Biol, 2017
Walker SS, Degen D, Nickbarg E, Carr D, Soriano A, Mandal M, Painter RE, Sheth P, Xiao L, Sher X, Murgolo N, Su J, Olsen DB, Ebright RH, Young K.   +14 more
europepmc   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Affinity selection-mass spectrometry in the discovery of anti-SARS-CoV-2 compounds. [PDF]

Mass Spectrom Rev
van Breemen RB, Muchiri RN.
europepmc   +1 more source

Biotin-tagged proteins: Reagents for efficient ELISA-based serodiagnosis and phage display-based affinity selection. [PDF]

PLoS One, 2018
Verma V, Kaur C, Grover P, Gupta A, Chaudhary VK.   +4 more
europepmc   +1 more source