Results 1 to 10 of about 532,969 (259)

Expression of recombinant Antibodies [PDF]

Frontiers in Immunology, 2013
Recombinant antibodies are highly specific detection probes in research, diagnostics and have emerged over the last two decades as the fastest growing class of therapeutic proteins.
André eFrenzel, Michael eHust, Thomas eSchirrmann   +2 more
doaj   +4 more sources

Recombinant Antibodies against Mycolactone [PDF]

Toxins, 2019
In the past, it has proved challenging to generate antibodies against mycolactone, the primary lipidic toxin A of Mycobacterium ulcerans causing Buruli ulcer, due to its immunosuppressive properties.
Leslie Naranjo, Fortunato Ferrara, Nicolas Blanchard, Caroline Demangel, Sara D’Angelo, M. Frank Erasmus, Andre A. Teixeira, Andrew R.M. Bradbury   +7 more
doaj   +5 more sources

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies [PDF]

Frontiers in Immunology, 2022
Hyper-immune antisera from large mammals, in particular horses, are routinely used for life-saving anti-intoxication intervention. While highly efficient, the use of these immunotherapeutics is complicated by possible recipient reactogenicity and limited
Ronit Rosenfeld, Ron Alcalay, Anat Zvi, Alon Ben-David, Tal Noy-Porat, Theodor Chitlaru, Eyal Epstein, Ofir Israeli, Shirley Lazar, Noa Caspi, Ada Barnea, Eyal Dor, Inbar Chomsky, Shani Pitel, Efi Makdasi, Ran Zichel, Ohad Mazor   +16 more
doaj   +2 more sources

Research Progress in Affinity Enhancement Strategies for Recombinant Antibodies against Food Hazards [PDF]

Shipin Kexue, 2023
As a new generation of genetically engineered antibodies, recombinant antibodies are widely used in immunodetection of food hazards due to their simple structure as well as easy expression and modification.
WANG Feng, XIE Xi, MA Lukai, WANG Qin, XIAO Gengsheng, SHEN Yudong, XU Zhenlin, WANG Hong
doaj   +1 more source

Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy

Molecular Therapy: Oncolytics, 2023
CD47 and its receptor signal regulatory protein α (SIRPα) act as a dominant antiphagocytic, “don’t eat me” signal. Recent studies reveal CD24 as a novel target for cancer immunotherapy by macrophages in ovarian cancer and breast cancer.
Yun Yang, He Wu, Yan Yang, Yan Kang, Runjia He, Bei Zhou, Huaizu Guo, Jing Zhang, Jianqin Li, Chunpo Ge, Tianyun Wang   +10 more
doaj   +1 more source

Method for obtaining recombinant antibodies produced by a cell line transduced with recombinant adenoviruses

Тонкие химические технологии, 2023
Objectives. To develop a technology for obtaining recombinant antibodies in a suspension culture of human HEK293 cells using transduction with recombinant adenovirus serotype 5 (rAd5) carrying genes expressing heavy and light chains of antibodies on the ...
E. S. Sedova, D. N. Shcherbinin, A. S. Bandelyuk, L. V. Verkhovskaya, N. Yu. Viskova, E. D. Avdonina, V. V. Prokofiev, E. I. Ryabova, I. B. Esmagambetov, K. A. Pervoykina, E. A. Bogacheva, A. A. Lysenko, M. M. Shmarov   +12 more
doaj   +1 more source

Selection of Ceratitis capitata (Diptera: Tephritidae) specific recombinant monoclonal phage display antibodies for prey detection analysis. [PDF]

PLoS ONE, 2012
Several recombinant antibodies against the Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), one of the most important pests in agriculture worldwide, were selected for the first time from a commercial phage display library ...
César Monzó, Alberto Urbaneja, Miguel Ximénez-Embún, Julia García-Fernández, José Luis García, Pedro Castañera   +5 more
doaj   +1 more source

Demystified… recombinant antibodies [PDF]

Journal of Clinical Pathology, 2004
Recombinant antibodies are important tools for biomedical research and are increasingly being used as clinical diagnostic/therapeutic reagents. In this article, a background to humanised antibodies is given, together with details of the generation of antibody fragments—for example, single chain Fv fragments.
Smith, K.A., Nelson, Paul N., Warren, Phil, Astley, S.J., Murray, Paul G., Greenman, J.   +5 more
openaire   +4 more sources

Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells

Frontiers in Bioengineering and Biotechnology, 2022
Recombinant antibodies are rapidly developing therapeutic agents; approximately 40 novel antibody molecules enter clinical trials each year, most of which are produced from Chinese hamster ovary (CHO) cells.
Jun-He Zhang, Jun-He Zhang, Jun-He Zhang, Lin-Lin Shan, Fan Liang, Chen-Yang Du, Jing-Jing Li   +6 more
doaj   +1 more source

Obtaining Recombinant Antigens for the Development of Serological Diagnosis of Marburg Fever

Проблемы особо опасных инфекций, 2021
Aim. Production of recombinant viral antigens of the main immunodominant proteins: glycoprotein (GPΔMLD), nucleoprotein (NP) and matrix protein (VP40) of the Marburg virus, as well as the study of their antigenic and immunogenic properties.Materials and ...
N. V. Volkova, A. V. Ivanova, A. A. Isaeva, O. A. Polezhaeva, A. V. Zaykovskaya, D. N. Shcherbakov, E. I. Kazachinskaya   +6 more
doaj   +1 more source