Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Recombinant antibodies are rapidly developing therapeutic agents; approximately 40 novel antibody molecules enter clinical trials each year, most of which are produced from Chinese hamster ovary (CHO) cells.
Jun-He Zhang +6 more
doaj +4 more sources
Rapid-format recombinant antibody-based methods for the diagnosis of Clostridioides difficile infection: Recent advances and perspectives [PDF]
Frontiers in Microbiology, 2022 Clostridioides difficile, the most common cause of nosocomial diarrhea, has been continuously reported as a worldwide problem in healthcare settings. Additionally, the emergence of hypervirulent strains of C.
Hamideh Raeisi +4 more
doaj +2 more sources
Development of Recombinant Antibody by Yeast Surface Display Technology [PDF]
Current Research in Pharmacology and Drug DiscoveryRecombinant antibodies have emerged as powerful tools in various fields, including therapeutics, diagnostics, and research applications. The selection of high-affinity antibodies with desired specificity is a crucial step in the development of ...
Mujahed I. Mustafa +2 more
doaj +2 more sources
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
mAbs, 2020 The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor C5, as well as anti-human CD14
Corinna Lau +10 more
doaj +3 more sources
Advances in recombinant antibody manufacturing. [PDF]
Appl Microbiol Biotechnol, 2016 Since the first use of Chinese hamster ovary (CHO) cells for recombinant protein expression, production processes have steadily improved through numerous advances. In this review, we have highlighted several key milestones that have contributed to the success of CHO cells from the beginning of their use for monoclonal antibody (mAb) expression until ...
Kunert R, Reinhart D.
europepmc +4 more sources
Recombinant Antibodies against Mycolactone
Toxins, 2019 In the past, it has proved challenging to generate antibodies against mycolactone, the primary lipidic toxin A of Mycobacterium ulcerans causing Buruli ulcer, due to its immunosuppressive properties.
Leslie Naranjo +7 more
doaj +4 more sources
Novel single-chain antibodies against highly conserved epitopes in the hemagglutinin of influenza A viruses: Promising agents for universal therapies [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Development of new antibodies with broad activity would provide anti-influenza prophylaxis and treatment. Human single-chain variable fragments (scFvs) are considered effective agents against viruses.
Samaneh Alizadeh +4 more
doaj +1 more source
Research Progress in Affinity Enhancement Strategies for Recombinant Antibodies against Food Hazards [PDF]
Shipin Kexue, 2023 As a new generation of genetically engineered antibodies, recombinant antibodies are widely used in immunodetection of food hazards due to their simple structure as well as easy expression and modification.
WANG Feng, XIE Xi, MA Lukai, WANG Qin, XIAO Gengsheng, SHEN Yudong, XU Zhenlin, WANG Hong
doaj +1 more source
Recombinant Antibody Fragments for Neurodegenerative Diseases [PDF]
Current Neuropharmacology, 2017 Karen Manoutcharian +1 more
exaly +2 more sources
Expression of Recombinant Antibodies [PDF]
Frontiers in Immunology, 2013 Recombinant antibodies are highly specific detection probes in research, diagnostics, and have emerged over the last two decades as the fastest growing class of therapeutic proteins. Antibody generation has been dramatically accelerated by in vitro selection systems, particularly phage display.
Frenzel, André +2 more
openaire +3 more sources