Results 21 to 30 of about 1,379,490 (255)

Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis [PDF]

, 2001
Neutralizing antibodies represent a major host defense mechanism against viral infections. In mammals, passive immunity is provided by neutralizing antibodies passed to the offspring via the placenta or the milk as immunoglobulin G and secreted ...
Pewe, L, John Webster, Whitelaw, C B, Andreas F. Kolb, Perlman, S, Siddell, S G, Stanley Perlman, C. Bruce A. Whitelaw, Stuart G. Siddell, Webster, J, Kolb, A F, Lecia Pewe   +11 more
core   +1 more source

Anti-VDAC3 recombinant antibody decreased human sperm motility and membrane integrity: A potential spermicide for contraception

Asian Pacific Journal of Reproduction, 2017
Objective: To express recombinant protein that comprises an important fragment of human sperm specific voltage dependent anion channel 3 (VDAC3) protein as a potential molecule for generation of antibody, which can affect sperm function, aiming at ...
Asmarinah, Tri Panjiasih Susmiarsih, Amalia Shari, Putri Ratri, Dwi Ari Pujianto, Endang Winiati Bachtiar   +5 more
doaj   +1 more source

Microarray of Recombinant Antibodies Using a Streptavidin Sensor Surface Self-Assembled onto a Gold Layer

BioTechniques, 2003
We have developed a sensitive method for the detection of recombinant antibody-antigen interactions in a microarray format. The biochip sensor platform used in this study is based on an oriented streptavidin monolayer that provides a biological interface
P. Pavlickova, A. Knappik, D. Kambhampati, F. Ortigao, H. Hug   +4 more
doaj   +1 more source

Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas [PDF]

, 2005
INTRODUCTION: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA).
Wels, Winfried, Sebastian Harder, Sibylle Loibl, Christian Cimpoiasu, Akin Atmaca, Cimpoiasu, C, Elke Jäger, Alexander Knuth, Dirk Jäger, Minckwitz, Gunter von, Neumann, A M, Harder, S, Cimpoiasu, Christian, Antje Neumann, Hövelmann, S, Winfried S Wels, Atmaca, Akin, Knuth, Alexander, Sascha Hövelmann, Abera, A, Abera, Aklil, Maurer, Alexander B., Gunter von Minckwitz, Aklil Abera, Al-Batran, S E, Knuth, A L, Loibl, S G, Hövelmann, Sascha, Jäger, Elke, Jäger, Dirk, Salah-Eddin Al-Batran, Alexander B Maurer, Loibl, Sibylle, Maurer, A B, Manfred Kaufmann, Wels, W S, von Minckwitz, G, Neumann, Antje, Jäger, D, Jäger, E, Atmaca, A, Kaufmann, M, Batran, Salah-Eddin al-, Kaufmann, Manfred, Harder, Sebastian, Maurer, Alexander B, von Minckwitz, Gunter, Wels, Winfried S, Al-Batran, Salah-Eddin   +48 more
core   +2 more sources

A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I

Molecular Therapy: Methods & Clinical Development, 2018
Antibodies against recombinant proteins can significantly reduce their effectiveness in unanticipated ways. We evaluated the humoral response of mice with the lysosomal storage disease mucopolysaccharidosis type I treated with weekly intravenous ...
Steven Q. Le, Shih-hsin Kan, Don Clarke, Valentina Sanghez, Martin Egeland, Kristen N. Vondrak, Terence M. Doherty, Moin U. Vera, Michelina Iacovino, Jonathan D. Cooper, Mark S. Sands, Patricia I. Dickson   +11 more
doaj   +1 more source

Fv antibodies to aflatoxin B1 derived from a pre-immunized antibody phage display library system [PDF]

, 2002
The production and characterization of recombinant antibodies to aflatoxin B[SUB1] (AFB[SUB1]), a potent mycotoxin and carcinogen is described. The antibody fragments produced were then applied for use in a surface plasmon resonance-based biosensor ...
Daly, Stephen J., Killard, Anthony J., Dunne, Lynsey, O\u27Kennedy, Richard, Dillon, Paul P., Manning, Bernadette M., O'Kennedy, Richard   +6 more
core   +2 more sources

A recombinant 9E1 monoclonal antibody binds membrane and soluble channel catfish immunoglobulin M

Fish and Shellfish Immunology Reports, 2023
The development and validation of the recombinant 9E1 monoclonal antibody against channel catfish IgM is described. The variable heavy and light chain domains of the 9E1 hybridoma were cloned into murine IgG1 and IgK expression vectors.
Miles D. Lange, Emily M. Churchman, Allison L. Wise, Timothy J. Bruce   +3 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart, Sharpe Sally A, Skinner Michael A, Dowall Stuart D, Dennis Mike J, Blanchard Tom J, Stewart James P, Anson Donald S, Bridge Simon H, Getty Brian   +53 more
core   +1 more source

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Rapp, Maria, Koszinowski, Ulrich H., Lucin, Pero, Messerle, Martin, Loh, Lambert C.   +4 more
core   +1 more source

Production of specific IgY antibody to the recombinant FanC protein produced in Escherichia coli [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Enterotoxigenic Escherichia coli (ETEC) strains are one of the primary causes of diarrhea in newborn calves and in humans, pigs, and sheep.
Khadijeh Nasiri, Saeed Zibaee, Mohammadreza Nassiri, Mojtaba Tahmoorespur, Alireza Haghparast   +4 more
doaj   +1 more source