Results 11 to 20 of about 237,834 (284)

Convergent transcription and nested gene models studied by AFM [PDF]

, 2012
Genomic DNA is organised in complex spatial arrangements, and a given stretch of DNA may encode more than one gene. In some cases one gene may be entirely contained within a region of the DNA already occupied by another larger gene. The presence of these
Billingsley, Daniel Jeffrey
core   +6 more sources

Imaging and NanoManipulation with AFM of bacterial samples in air and liquid environment [PDF]

, 2009
Màster Oficial en Enginyeria BiomèdicaSince the innovator speech of Nobel laureate Richard Feynman in the early 1959, the progress of nanotechnology has been a succession of inventions and developments.
Meta, Ijoni
core   +6 more sources

Reporting about value creation – Evidence from the Netherlands [PDF]

MAB, 2020
Value creation is a key element in transparent and informative reporting, as it gives a better impression of the risks and opportunities that a company faces.
Kavita Nandram, Mohamed El Harchaoui
doaj   +3 more sources

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle

Frontiers in Pharmacology, 2023
Introduction: Alteration in the development, maturation, and projection of dopaminergic neurons has been proposed to be associated with several neurological and psychiatric disorders.
Claire Boissart, Marie Lasbareilles, Marie Lasbareilles, Marie Lasbareilles, Johana Tournois, Laure Chatrousse, Thifaine Poullion, Alexandra Benchoua, Alexandra Benchoua   +8 more
doaj   +1 more source

NanoLocz: Image analysis platform for AFM, high-speed AFM and localization AFM

Small Methods, 2023
Abstract NanoLocz is an open-source computer program designed for high-throughput automatic processing and single-particle analysis of Atomic Force Microscopy (AFM) image data. High-Speed AFM and Localization AFM (LAFM) enable the study of single molecules with increasingly higher spatiotemporal resolution.
Heath, G.R., Micklethwaite, E., Storer, T.M.   +2 more
openaire   +4 more sources

CRISPR/Cas9-mediated generation of human embryonic stem cell sub-lines with HPRT1 gene knockout to model Lesch Nyhan disease

Stem Cell Research, 2023
Lesch-Nyhan disease (LND) is a X-linked genetic disease affecting boys characterized by complex neurological and neuropsychiatric symptoms. LND is caused by loss of function mutations in the HPRT1 gene leading to decrease activity of hypoxanthine-guanine
Claire Boissart, Laure Chatrousse, Thifaine Poullion, Lina El-Kassar, Karine Giraud-Triboult, Alexandra Benchoua   +5 more
doaj   +1 more source

Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9

Stem Cell Research, 2023
Phelan-McDermid syndrome (PMS) is a rare genetic disease characterized by a global developmental delay with autism spectrum disorder. PMS is caused by loss of function mutations in the SHANK3 gene leading to SHANK3 protein haploinsufficiency.
Laure Chatrousse, Thifaine Poullion, Lina El-Kassar, Karine Giraud-Triboult, Claire Boissart, Peggy Sanatine, Peter Sommer, Alexandra Benchoua   +7 more
doaj   +1 more source

Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders

Cells, 2021
One of the major obstacles to the identification of therapeutic interventions for central nervous system disorders has been the difficulty in studying the step-by-step progression of diseases in neuronal networks that are amenable to drug screening ...
Alexandra Benchoua, Marie Lasbareilles, Johana Tournois   +2 more
doaj   +1 more source

Empirical Analysis of the Elasticity of Employment to Output Gap in the Republic of Croatia [PDF]

Interdisciplinary Description of Complex Systems, 2021
This article deals with the impact of cyclical activity of GDP on employment in the Republic of Croatia in the period from 2000 to 2020. According to the prevailing economic paradigm, employment growth follows GDP growth in the long run, but cyclical ...
Željko Kučiš, Irena Palić
doaj   +1 more source

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

Cells, 2021
The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues.
Margot Jarrige, Elie Frank, Elise Herardot, Sabrina Martineau, Annabelle Darle, Manon Benabides, Sophie Domingues, Olivier Chose, Walter Habeler, Judith Lorant, Christine Baldeschi, Cécile Martinat, Christelle Monville, Lise Morizur, Karim Ben M’Barek   +14 more
doaj   +1 more source