Results 21 to 30 of about 211,078 (328)

A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma

Annals medicus, 2022
Background Hepatocellular carcinoma lacks ideal diagnostic biomarkers. There is a lack of scientific evaluation of relevant promising biomarkers as well.
Bing-yao Pang, Yan Leng, Xiaoli Wang, Yi-qiang Wang, Li-hong Jiang   +4 more
semanticscholar   +1 more source

Reductions in AFP and PIVKA-II can predict the efficiency of anti-PD-1 immunotherapy in HCC patients

BMC Cancer, 2021
Background Few biomarkers can predict the efficiency of PD-1 blockade in patients with hepatocellular carcinoma (HCC). This study aimed to investigate the prognostic role of AFP and PIVKA-II in HCC patients receiving anti-PD-1 immunotherapy.
Xuqi Sun, Jie Mei, Wenping Lin, Ziliang Yang, W. Peng, Jinbin Chen, Yaojun Zhang, Li Xu, Minshan Chen   +8 more
semanticscholar   +1 more source

Assessing mortgage default risk in full-recourse economies, with an application to the case of Chile

Latin American Journal of Central Banking, 2020
This paper is aimed at finding individual and systemic determinants of housing default in a full-recourse economy. We propose an empirical strategy that accounts for rare events and choice-based sampling bias and estimates the contribution of ...
Diego Avanzini, Juan Francisco Martı́nez, Vı́ctor Pérez   +2 more
doaj   +1 more source

The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

PLoS ONE, 2020
Objective Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery.
Jiaxin Zhang, Guang Chen, Peng Zhang, Jiaying Zhang, Xiaoke Li, Danan Gan, Xu Cao, Mei Han, Hongbo Du, Y. Ye   +9 more
semanticscholar   +1 more source

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma

BMC Cancer, 2021
Background Icaritin, an active ingredient of the Chinese herb Epimedium, plays an anti-tumor role in liver cancer by inhibiting the proliferation of hepatocellular cells and promoting their apoptosis.
Hui Li, Yujuan Liu, Wei Jiang, Junhui Xue, Yuning Cheng, Jiyin Wang, Ruixiang Yang, Xiaowei Zhang   +7 more
semanticscholar   +1 more source

Alpha-fetoprotein detection of hepatocellular carcinoma leads to a standardized analysis of dynamic AFP to improve screening based detection [PDF]

, 2016
Detection of hepatocellular carcinoma (HCC) through screening can improve outcomes. However, HCC surveillance remains costly, cumbersome and suboptimal. We tested whether and how serum Alpha-Fetoprotein (AFP) should be used in HCC surveillance.
Ahn, Sang Hoon, Bird, Sheila M., Bird, Thomas G., Blunsum, Andrew, Cusack, Pearce, Dimitropoulou, Polyxeni, Hayes, Peter C., Hey, Shiying, Jenks, Sara J., Kelly, Sarah, Sturgeon, Catharine, Turner, Rebecca M.   +11 more
core   +4 more sources

New Blood Biomarkers for the Diagnosis of AFP-Negative Hepatocellular Carcinoma

Frontiers in Oncology, 2020
An early diagnosis of hepatocellular carcinoma (HCC) followed by effective treatment is currently critical for improving the prognosis and reducing the associated economic burden.
Ting Wang, Kun-He Zhang
semanticscholar   +1 more source

AFP-L3 for the diagnosis of early hepatocellular carcinoma

Medicine, 2021
Background: The present study aimed to systematically evaluate the diagnostic value of an isoform of alpha-fetoprotein (AFP), AFP-L3, for early hepatocellular carcinoma (HCC) by a meta-analysis.
Jian-Ming Zhou, Ting Wang, Kun-He Zhang
semanticscholar   +1 more source

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

Cell Death and Disease, 2020
Hepatocellular carcinoma (HCC) is a major leading cause of cancer-related death worldwide. Alpha fetoprotein (AFP) is reactivated in a majority of hepatocellular carcinoma (HCC) and associated with poor patient outcomes.
Tianke Chen, Xiaowei Dai, Juji Dai, Chaodong Ding, Zheng Zhang, Ziqi Lin, Jin Hu, Mei Lu, Zhanyu Wang, Yalei Qi, Li Zhang, Rulu Pan, Zhu Zhao, Liting Lu, Wanqin Liao, Xincheng Lu   +15 more
semanticscholar   +1 more source

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients

Disease Markers, 2021
Background At present, the diagnostic accuracy of alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) surveillance is insufficient. It remains controversial whether prothrombin induced by vitamin K absence II (PIVKA-II) has a better diagnostic ...
Fei Xu, Lulu Zhang, Wenting He, Di Song, Xiaomeng Ji, J. Shao   +5 more
semanticscholar   +1 more source