Results 71 to 80 of about 45,459 (317)

Recent progress on gene-deleted live-attenuated African swine fever virus vaccines

npj Vaccines
African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security ...
Hiep L. X. Vu, D. S. McVey
semanticscholar   +1 more source

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge

Journal of Virology, 2022
Currently, the deficiency in commercially available vaccines or therapeutic options against African swine fever constitutes a matter of major concern in the swine industry globally. Here, we report the design and construction of a recombinant ASFV mutant
Mingyang Ding, W. Dang, Huanan Liu, Fan Xu, Huaguo Huang, Yongjie Sunkang, Tao Li, Jingjing Pei, Xiang-tao Liu, Yong Zhang, Haixue Zheng   +10 more
semanticscholar   +1 more source

Epidemiology of African swine fever virus

Virus Research, 2013
African swine fever virus used to occur primarily in Africa. There had been occasional incursions into Europe or America which apart from the endemic situation on the island of Sardinia always had been successfully controlled. But following an introduction of the virus in 2007, it now has expanded its geographical distribution into Caucasus and Eastern
Costard, S., Mur, L., Lubroth, J., Sánchez Vizcaino, J.M., Pfeiffer, Dirk U.   +4 more
openaire   +4 more sources

African Swine Fever Virus as a Difficult Opponent in the Fight for a Vaccine—Current Data

Viruses, 2021
Prevention and control of African swine fever virus (ASFV) in Europe, Asia, and Africa seem to be extremely difficult in view of the ease with which it spreads, its high resistance to environmental conditions, and the many obstacles related to the ...
Hanna Turlewicz-Podbielska, Anna Kuriga, Rafał Niemyjski, Grzegorz Tarasiuk, Małgorzata Pomorska-Mól   +4 more
doaj   +1 more source

African Swine Fever Virus EP364R and C129R Target Cyclic GMP-AMP To Inhibit the cGAS-STING Signaling Pathway

Journal of Virology, 2022
African swine fever (ASF) is a highly contagious hemorrhagic disease in domestic pigs and wild boars caused by African swine fever virus (ASFV). ASF is a deadly epidemic disease in the global pig industry, but no drugs or vaccines are available. ABSTRACT
Niranjan Dodantenna, L. Ranathunga, W. A. G. Chathuranga, Asela Weerawardhana, J. Cha, Ashan Subasinghe, Nuwan Gamage, D. K. Haluwana, Yongkwan Kim, W. Jheong, H. Poo, Jong-Soo Lee   +11 more
semanticscholar   +1 more source

Development and In Vivo Evaluation of a MGF110-1L Deletion Mutant in African Swine Fever Strain Georgia

Viruses, 2021
African swine fever (ASF) is currently causing an epizootic, affecting pigs throughout Eurasia, and causing significant economic losses in the swine industry.
Elizabeth Ramirez-Medina, Elizabeth Vuono, Sarah Pruitt, Ayushi Rai, Ediane Silva, Nallely Espinoza, James Zhu, Lauro Velazquez-Salinas, Manuel V. Borca, Douglas P. Gladue   +9 more
doaj   +1 more source

Single-cell profiling of African swine fever virus disease in the pig spleen reveals viral and host dynamics

Proceedings of the National Academy of Sciences of the United States of America
Significance African swine fever is arguably the most severe infectious disease threating the global pig industry. However, how African swine fever virus (ASFV) manipulates the infected cell population and controls host responses to drive high-efficient ...
Zixiang Zhu, R. Mao, Baohong Liu, Huanan Liu, Zhengwang Shi, Kunpeng Zhang, Huisheng Liu, Danyang Zhang, Jia Liu, Zhenxiang Zhao, Kangli Li, Fan Yang, W. Cao, Xiangle Zhang, Chao-chao Shen, Dehui Sun, Liyuan Wang, H. Tian, Yi Ru, Tao Feng, Jijun He, Jian-hong Guo, Keshan Zhang, Zhonglin Tang, Shilei Zhang, Chan Ding, Jun Han, Haixue Zheng   +27 more
semanticscholar   +1 more source

African Swine Fever Virus and Host Response: Transcriptome Profiling of the Georgia 2007/1 Strain and Porcine Macrophages

Journal of Virology, 2022
African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, with case fatality rates approaching 100% and no approved vaccines or antivirals.
G. Cackett, Raquel Portugal, D. Matelska, L. Dixon, F. Werner   +4 more
semanticscholar   +1 more source

Emergence of African Swine Fever Virus, Northwestern Iran

Emerging Infectious Diseases, 2010
In 2008, African swine fever was introduced into Georgia, after which it spread to neighboring Armenia, Azerbaijan, and the Russian Federation. That same year, PCR and sequence analysis identified African swine fever virus in samples from 3 dead female ...
Pooneh Rahimi, Amir Sohrabi, Javad Ashrafihelan, Rosita Edalat, Mehran Alamdari, Mohammadhossein Masoudi, Saied Mostofi, Kayhan Azadmanesh   +7 more
doaj   +1 more source

Adaptive Cellular Immunity against African Swine Fever Virus Infections

Pathogens, 2022
African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs.
Alexander Schäfer, G. Franzoni, C. Netherton, L. Hartmann, S. Blome, U. Blohm   +5 more
semanticscholar   +1 more source