Results 101 to 110 of about 1,681,802 (268)

Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia [PDF]

, 2015
Background: Ethiopia, particularly in the Northwest region, is affected by both tsetse and non-tsetse fly transmitted trypanosomosis, with significant impact on livestock productivity. The aim of this study was to determine and compare clinical findings
Abebe, Getachew, Barry, J. David, Bezie, Melkamu, Dagnachew, Shimelis, Goddeeris, Bruno M., Terefe, Getachew   +5 more
core   +2 more sources

Monitoring the elimination of human African trypanosomiasis: Update to 2014

PLoS Neglected Tropical Diseases, 2017
Background The World Health Organization (WHO) has targeted the elimination of Human African trypanosomiasis (HAT) ‘as a public health problem’ by 2020.
J. Franco, G. Cecchi, G. Priotto, M. Paone, A. Diarra, L. Grout, R. Mattioli, D. Argaw   +7 more
semanticscholar   +1 more source

Modulation of succinyl‐CoA:3‐ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Trypanosomatids are protozoan parasites that remain a global health challenge due to the limited efficacy, safety, and durability of current treatments. Acetate: succinate CoA transferase (ASCT), together with succinyl‐CoA synthase (SCS), forms the ASCT/SCS cycle that fuels ATP production and generates acetate, a central metabolic intermediate
Kota Mochizuki, Daniel Ken Inaoka, Keisuke Fukuda, Hana Kurasawa, Kenji Iyoda, Uta Nakai, Shigeharu Harada, Emmanuel O. Balogun, Frédéric Bringaud, Michael Boshart, Takaya Sakura, Kenji Hirayama, Kiyoshi Kita, Tomoo Shiba   +13 more
wiley   +1 more source

African animal trypanosomiasis as a constraint to livestock health and production in Karamoja region: a detailed qualitative and quantitative assessment

BMC Veterinary Research, 2017
Background Nagana (African Animal Trypanosomiasis-AAT) and tick-borne diseases (TBDs) constrain livestock production in most parts of sub-Saharan Africa.
Dennis Muhanguzi, Albert Mugenyi, Godfrey Bigirwa, Maureen Kamusiime, Ann Kitibwa, Grace Gloria Akurut, Sylvester Ochwo, Wilson Amanyire, Samuel George Okech, Jan Hattendorf, Robert Tweyongyere   +10 more
doaj   +1 more source

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira, Mariana Cintra Pagotti, Lucas Antonio de Lima Paula, Mariana Zaramello Paixão, Daiane Albino dos Santos, Renata Faleiros de Freitas, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

Microfluidics-based approaches to the isolation of African trypanosomes [PDF]

, 2017
African trypanosomes are responsible for significant levels of disease in both humans and animals. The protozoan parasites are free-living flagellates, usually transmitted by arthropod vectors, including the tsetse fly. In the mammalian host they live in
Barrett, Michael P., Beech, Jason P., Cooper, Jonathan M., Hochstetter, Axel, Holm, Stefan H., Regnault, Clément, Tegenfeldt, Jonas O.   +6 more
core   +3 more sources

Breast Health Training Program for Traditional Healers: A Pathway to Early Breast Cancer Detection in Tanzania

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background In sub‐Saharan Africa, traditional healers often serve as primary healthcare providers and are the first point of contact for patients. Given this, they are uniquely positioned to aid in early breast cancer detection. To evaluate this, we implemented a breast cancer training program to equip traditional healers in Tanzania with ...
Autumn Beavers, Elizabeth F. Msoka, Irene Masue, Theresia Mwakyembe Mwansasu, Ayesiga Herman, Blandina T. Mmbaga, Lily Gutnik   +6 more
wiley   +1 more source

Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis

Frontiers in Immunology, 2019
Parasites, including African trypanosomes, utilize several immune evasion strategies to ensure their survival and completion of their life cycles within their hosts.
Chukwunonso Onyilagha, J. Uzonna
semanticscholar   +1 more source

In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei

Advances in Pharmacological and Pharmaceutical Sciences, 2022
African trypanosomiasis is a major neglected tropical disease with significant health and economic concerns in sub-Saharan Africa. In the absence of vaccines for African trypanosomiasis, there is a consideration for alternative sources of chemotherapy ...
Aboagye Kwarteng Dofuor, Temitayo Samson Ademolue, Karen Nana Akua Kuampah, Frederick Ayertey, Theresa Manful Gwira   +4 more
doaj   +1 more source

Molecular epidemiology of African sleeping sickness [PDF]

, 2009
Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT, G. HIDE, Gibson, Hide, Mehlitz, Morrison   +5 more
core   +2 more sources