Results 21 to 30 of about 1,681,802 (268)

Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies

PLoS Neglected Tropical Diseases, 2020
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for
Joseph Mathu Ndung’u, Alain Boulangé, Albert Picado, Albert Mugenyi, Allan Mortensen, Andrew Hope, Brahim Guihini Mollo, Bruno Bucheton, Charles Wamboga, Charles Waiswa, Dramane Kaba, Enock Matovu, Fabrice Courtin, Gala Garrod, Geoffrey Gimonneau, Georgina V. Bingham, Hassane Mahamat Hassane, Iñaki Tirados, Isabel Saldanha, Jacques Kaboré, Jean-Baptiste Rayaissé, Jean-Mathieu Bart, Jessica Lingley, Johan Esterhuizen, Joshua Longbottom, Justin Pulford, Lingué Kouakou, Lassina Sanogo, Lucas J. Cunningham, Mamadou Camara, Mathurin Koffi, Michelle C. Stanton, Mike Lehane, Moïse Kagbadouno, Oumou Camara, Paul R. Bessell, Mallaye Péka, Philippe Solano, Richard Selby, Sophie Dunkley, Stephen J. Torr, Sylvain Biéler, Veerle Lejon, Vincent Jamonneau, Wilfried Yoni, Zachary Katz   +45 more
openalex   +3 more sources

African Trypanosomiasis [PDF]

Definitions, 2020
Introduction Definition African trypanosomiasis is infection by protozoan hemoflagellates of the Trypanosoma brucei complex, 2 subspecies of which cause disease in humans: Trypanosoma brucei gambiense causes Gambian (chronic) trypanosomiasis and ...
Sanjeev Krishna, Christian Kleine, August Stich   +2 more
semanticscholar   +6 more sources

Human African Trypanosomiasis (sleeping sickness): Current knowledge and future challenges

Frontiers in Tropical Diseases, 2023
According to both definitions of US Centers for Disease Control and Prevention and World Health Organization, Neglected Tropical Diseases (NTDs) are a group of preventable and treatable parasitic, viral, and bacterial diseases that affect more than one ...
Roberta Papagni, Roberta Novara, Maria Letizia Minardi, Luisa Frallonardo, G. Panico, Elisabetta Pallara, Sergio Cotugno, Tommaso Ascoli Bartoli, Giacomo Guido, Elda De Vita, A. Ricciardi, Valentina Totaro, Michele Camporeale, F. Segala, D. Bavaro, Giulia Patti, G. Brindicci, C. Pellegrino, Michele Mariani, G. Putoto, L. Sarmati, C. Castellani, A. Saracino, Francesco Di Gennaro, E. Nicastri   +24 more
semanticscholar   +1 more source

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis. [PDF]

EBioMedicine, 2022
Sima N, Dujeancourt-Henry A, Perlaza BL, Ungeheuer MN, Rotureau B, Glover L.   +5 more
europepmc   +2 more sources

The elimination of human African trypanosomiasis: Achievements in relation to WHO road map targets for 2020

PLoS Neglected Tropical Diseases, 2022
Background In the 20th century, epidemics of human African trypanosomiasis (HAT) ravaged communities in a number of African countries. The latest surge in disease transmission was recorded in the late 1990s, with more than 35,000 cases reported annually ...
J. Franco, G. Cecchi, M. Paone, A. Diarra, L. Grout, Augustin Kadima Ebeja, P. Simarro, Weining Zhao, D. Argaw   +8 more
semanticscholar   +1 more source

An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

Molecules, 2021
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and leishmaniases span worldwide and therefore their impact is a universal concern.
Violeta Kourbeli, E. Chontzopoulou, Kalliopi Moschovou, Dimitrios Pavlos, T. Mavromoustakos, Ioannis P. Papanastasiou   +5 more
semanticscholar   +1 more source

The Pathogenesis of African Trypanosomiasis.

Annual Review of Pathology, 2022
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts.
E. Pays, M. Radwanska, S. Magez
semanticscholar   +1 more source

Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this ...
Jan Medlock, Katherine E Atkins, David N Thomas, Serap Aksoy, Alison P Galvani   +4 more
doaj   +1 more source

An atlas of tsetse and animal African trypanosomiasis in Zimbabwe

Parasites & Vectors, 2021
In the 1980s and 1990s, great strides were taken towards the elimination of tsetse and animal African trypanosomiasis (AAT) in Zimbabwe. However, advances in recent years have been limited.
W. Shereni, L. Neves, R. Argilés, Learnmore Nyakupinda, G. Cecchi   +4 more
semanticscholar   +1 more source

Human African trypanosomiasis : current status and eradication efforts [PDF]

, 2020
Epidemics of human African trypanosomiasis (HAT) in the 20th century led to millions of deaths. However, since the start of the twenty-first century, there is been a continued decline in the number of reported cases, due to increased investment and ...
Davis, Christopher, Keeling, Matthew James, Rock, Kat S.   +2 more
core   +1 more source