Results 31 to 40 of about 1,681,802 (268)

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Nature Communications, 2021
The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the production of
I. McNae, James Kinkead, Divya Malik, L. Yen, Martin K. Walker, Chris Swain, S. Webster, N. Gray, P. Fernandes, E. Myburgh, E. Blackburn, Ryan Ritchie, Carol Austin, M. Wear, Adrian J. Highton, A. Keats, A. Vong, J. Dornan, J. Mottram, P. Michels, S. Pettit, M. Walkinshaw   +21 more
semanticscholar   +1 more source

Unusual neurological presentation of second stage African trypanosomiasis in a young boy: a case report

BMC Pediatrics, 2022
Background In South Sudan, sleeping sickness is a frequent condition caused by human African trypanosomiasis. There are two stages that are well-known.
Etedal Ahmed A. Ibrahim, Mohammed Gasm Elseed M. Elmahal, Khabab Abbasher Hussien Mohamed Ahmed, Elfatih A. Hasabo, Mohammed Eltahier Abdalla Omer   +4 more
doaj   +1 more source

Potential impacts of climate change on geographical distribution of three primary vectors of African Trypanosomiasis in Tanzania’s Maasai Steppe: G. m. morsitans, G. pallidipes and G. swynnertoni

PLoS Neglected Tropical Diseases, 2021
In the Maasai Steppe, public health and economy are threatened by African Trypanosomiasis, a debilitating and fatal disease to livestock (African Animal Trypanosomiasis -AAT) and humans (Human African Trypanosomiasis—HAT), if not treated.
H. Nnko, P. Gwakisa, Anibariki Ngonyoka, C. Sindato, A. Estes   +4 more
semanticscholar   +1 more source

The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana. [PDF]

Am J Trop Med Hyg
Tweneboah A, Rosenau J, Addo KA, Addison TK, Ibrahim MAM, Weber JS, Kelm S, Badu K.   +7 more
europepmc   +3 more sources

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

African trypanosomiasis [PDF]

Annals of Tropical Medicine & Parasitology, 2006
Trypanosomiasis remains one of the most serious constraints to economic development in sub-Saharan Africa and, as a consequence, related research has been subject to strong social and political as well as scientific influences. The epidemics of sleeping sickness that occurred at the turn of the 20th Century focussed research efforts on what became ...
  +5 more sources

Potential applicability of the importation risk index for predicting the risk of rarely imported infectious diseases

BMC Public Health, 2023
Background There have been many prediction studies for imported infectious diseases, employing air-travel volume or the importation risk (IR) index, which is the product of travel-volume and disease burden in the source countries, as major predictors ...
Kyung-Duk Min, Sun-Young Kim, Yoon Young Cho, Seyoung Kim, Joon-Sup Yeom   +4 more
doaj   +1 more source

Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018

PLoS Neglected Tropical Diseases, 2020
Background In 2012 human African trypanosomiasis (HAT), also known as sleeping sickness, was targeted for elimination as a public health problem, set to be achieved by 2020.
J. Franco, G. Cecchi, G. Priotto, M. Paone, A. Diarra, L. Grout, P. Simarro, Weining Zhao, D. Argaw   +8 more
semanticscholar   +1 more source

Transmission concomitante de trypanosomose humaine et animale : le foyer de Mandoul au Tchad

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2014
La trypanosomose est une maladie qui affecte à la fois l’homme et les animaux. Elle est provoquée par Trypanosoma sp. et cycliquement transmise par un vecteur, la glossine.
Peka Mallaye, L. Kohagne Tongué, N. Ndeledje, F. J. Louis, H. Mahamat Hassane   +4 more
doaj   +1 more source

New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story

Tropical Medicine and Infectious Disease, 2020
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success ...
Emily A. Dickie, Federica Giordani, M. Gould, P. Mäser, C. Burri, J. Mottram, Srinivasa P. S. Rao, M. Barrett   +7 more
semanticscholar   +1 more source