Results 31 to 40 of about 183,083 (248)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Science Technology and Engineering Journal (STEJ), 2021 The first karyological analysis of the Sternocera ruficornis(Coleoptera, Buprestidae) was achieved by using the squash technique collected from the male gonad.
Nawarat Muanglen +4 more
doaj
Karyotypic evolution of ribosomal sites in buffalo subspecies and their crossbreed
Genetics and Molecular Biology, 2014 Domestic buffaloes are divided into two group based on cytogenetic characteristics and habitats: the "river buffaloes" with 2n = 50 and the "swamp buffaloes", 2n = 48. Nevertheless, their hybrids are viable, fertile and identified by a 2n = 49.
Tiago Marafiga Degrandi +9 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Amount variability of total and individual Ag-NOR proteins in cells stimulated to proliferate. [PDF]
Journal of Histochemistry & Cytochemistry, 1995 Ribosomal genes are associated with a subset of acidic proteins called Ag-NOR proteins. The amount of nucleolar Ag-NOR proteins varies, depending on nucleolar activity and/or cell proliferation. To understand the linkage between the amount of Ag-NOR proteins, ribosome biogenesis, and cell proliferation, we investigated the variability of Ag-NOR ...
V, Sirri +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A new karyotypic formula for the genus Amphisbaena (Squamata: Amphisbaenidae) [PDF]
Phyllomedusa: Journal of Herpetology, 2010 To contribute to the knowledge of chromosome evolution in Amphisbaena, we describe the karyotype constitution and the NOR location of Amphisbaena bolivica Mertens, 1929.
Camila Falcione, Alejandra Hernando
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Genetics and Molecular Biology, 2013 Cytogenetic studies in birds are still scarce compared to other vertebrates. Woodcreepers (Dendrocolaptidae) are part of a highly specialized group within the Suboscines of the New World.
Marcelo de Oliveira Barbosa +5 more
doaj
Variation in size and location of the Ag-NOR in the Atlantic halibut (Hippoglossus hippoglossus)
Genetica, 2007 The distribution of differentially stained chromatin was studied in the Atlantic halibut (Hippoglossus hippoglossus) chromosomes (2n=48). Four pairs of homologous chromosomes were identified using a combination of traditional cytogenetic staining techniques (Giemsa/DAPI/CMA3/Ag-NO3).
Ocalewicz, Konrad +2 more
openaire +3 more sources