Results 61 to 70 of about 4,861,017 (267)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multiphase density functional theory parameterization of the Gupta potential for silver and gold

, 2012
The ground state energies of Ag and Au in the face-centered cubic (FCC), body-centered cubic (BCC), simple cubic (SC) and the hypothetical diamond-like phase, and dimer were calculated as a function of bond length using density functional theory (DFT ...
Karttunen, Mikko, Titantah, John T.
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Effect of single and combined (core/shell) biosynthesis of nanoparticles (Ag and ZnO) on their photocatalytic and antimicrobial activities

Kuwait Journal of Science
Synthetic silver (Ag) and zinc oxide (ZnO) nanoparticles, singly or in core/shell form, have received significant attention for their numerous biomedical and health applications. This is due to their biocompatible, non-toxic, and catalytic nature.
doaj   +1 more source

Molecular identification of a Bacillus cereus strain from Murrah buffalo milk showed in vitro bioremediation properties on selective heavy metals

Journal of Advanced Veterinary and Animal Research, 2020
Objective: This study aims for molecular identification of naturally growing Bacillus cereus strain from a unique source, able to survive, and alleviate heavy metals from the nature.
Salauddin Al Azad, Mithila Farjana, Bipasha Mazumder, Md. Abdullah-Al-Mamun, A. B. M. Inamul Haque   +4 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Polimerik Güneş Hücrelerinde Ag Nanopartikül Katkılı TiO2 Tampon Tabakasının Kendiliğinden Organize Olan Tek Tabaka Moleküller (SAM) ile Modifiye Edilmesi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2020
Organik güneş hücrelerininperformansları üzerinde yüzey modifikasyonu ve metal nanopartiküller önemli birrol oynamaktadır. Tek tabaka kendiliğinden organize olan (self assemblymonolayer, SAM) organik malzemeler ucuz ve kolay uygulanabilir ...
Mustafa Can, Semih Yurtdaş, Cem Tozlu, Mustafa Karaman   +3 more
doaj  

Driving forces for Ag-induced periodic faceting of vicinal Cu(111)

, 2002
Adsorption of submonolayer amounts of Ag on vicinal Cu(111) induces periodic faceting. The equilibrium structure is characterized by Ag-covered facets that alternate with clean Cu stripes. In the atomic scale, the driving force is the matching of Ag(111)-
A. Mugarza, A.R. Bachmann, Aoki, Bachmann, Fölsch, Fölsch, Giesen, Hannon, Henzler, Himpsel, Horn von Hoegen, Ibach, J.E. Ortega, Liu, Maday, Marchenko, Men, Meunier, Meyer zu Heringdorf, Minoda, Minoda, Ng, Nien, Plass, Rousset, S. Speller, Seehofer, Shchukin, Tersoff, Vanderbilt   +29 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Scientific Reports, 2021
Non-alcoholic steatohepatitis (NASH) is a progressive and severe liver disease, characterized by lipid accumulation, inflammation, and downstream fibrosis. Despite its increasing prevalence, there is no approved treatment yet available for patients. This
Simon Ströbel, Radina Kostadinova, Katia Fiaschetti-Egli, Jana Rupp, Manuela Bieri, Agnieszka Pawlowska, Donna Busler, Thomas Hofstetter, Katarzyna Sanchez, Sue Grepper, Eva Thoma   +10 more
doaj   +1 more source