Results 111 to 120 of about 18,093 (282)

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily [PDF]

, 2016
Background: The association between aberrant signal processing by protein kinases and human diseases such as cancer was established long time ago.
Brunak, Søren, Gonzalez-Izarzugaza, Jose Maria, Matey-Hernandez, María Luisa, Pons, Tirso, Valencia, Alfonso, Vazquez, Miguel   +5 more
core   +4 more sources

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia [PDF]

, 2014
Bruton's tyrosine kinase (BTK) is a cytoplasmic protein found in all hematopoietic cell lineages except for T cells. BTK mediates signalling downstream of a number of receptors.
Advani, Alam, Ashino, Baba, Bendall, Billottet, Burger, Burger, Byrd, Chang, Cordle, Dasmahapatra, David J. MacEwan, de Weers, Dos Santos, Doyle, Fiedler, Gallay, Grandage, Gu, Guzman, Hahn, Herman, Herrmann, Honda, Honigberg, Horwood, Ishii, Juliusson, Kawakami, Kim, Kojima, Kristian M. Bowles, Kvinlaug, Lyubov Zaitseva, Megan Y. Murray, Min, Mohamed, Nanri, Park, Quek, Renneville, Rushworth, Rushworth, Rushworth, Shinners, Sivina, Spiekermann, Stuart A. Rushworth, Sujobert, Tai, Tamburini, Tomasson, Tsukada, Vellenga, Venkataraman, Vetrie, Welch, Westermann, Zaitseva   +59 more
core   +1 more source

Chronic Enteroviral Meningoencephalitis in a Boy with X-Linked Agammaglobulinemia [PDF]

, 2000
Os autores apresentam um caso clínico de encefalite crónica a enterovírus num rapaz de 9 anos com agamaglobulinémia congénita ligada ao cromossoma X (doença de Bruton). Apesar da terapêutica intraventricular com doses elevadas de gamaglobulina, registou-
Alves, A, Cabral, P, Dias, AI, Fialho, M, Martins, M   +4 more
core  

A Novel BTK Gene Mutation in a Child With Atypical X-Linked Agammaglobulinemia and Recurrent Hemophagocytosis: A Case Report

Frontiers in Immunology, 2019
X-linked agammaglobulinemia (XLA), caused by a mutation in the Bruton's tyrosine kinase (BTK) gene, is rarely reported in patients with recurrent hemophagocytic lymphohistiocytosis (HLH).
Shu-Ping Han, Yung-feng Lin, Hui-Ying Weng, S. Tsai, L. Fu   +4 more
semanticscholar   +1 more source

Agammaglobulinemia ligada A X Y onicodistrofia: dos nuevas mutaciones en el gen BTK y exclusión de mutaciones en el gen SOX9

Iatreia, 2010
La agammaglobulinemia ligada al cromosoma X ó Agammaglobulinemia de Bruton es una inmunodeficiencia que se caracteriza por ausencia de algunas inmunoglobulinas séricas, disminución de los linfocitos B tanto en la médula ósea como en la sangre periférica,
Carolina Rivera Nieto, Taryn Castro, Carlos Olmos, Carlos M. Restrepo, Paul Laissue   +4 more
doaj  

Summary of Papers Presented at the 45th Annual McGuire Lecture Series [PDF]

, 1974
It is the purpose of this presentation to quickly review some of the important points of the papers which were presented at the 45th Annual McGuire Lecture Series on the subject of immunology and rheumatic ...
Irby, Robert
core   +1 more source

A distinct role for B1b lymphocytes in T cell-independent immunity [PDF]

, 2008
Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases.
A Faili, A Scorpio, A Vink, A Zandvoort, A Zandvoort, AA Belperron, AB Kantor, AB Kantor, AB Satterthwaite, AF Ochsenbein, AG Barbour, AG Barbour, AM Stall, C Janeway, CA Jefferies, CA Jefferies, CD Landers, CG Vinuesa, CG Vinuesa de, CM Snapper, D Cadavid, D Tarlinton, DD Pinschewer, DE Briles, DE Mosier, DE Mosier, DF Amsbaugh, DF Kelly, DF Kelly, E Fikrig, E Montecino-Rodriguez, E Montecino-Rodriguez, E Szomolanyi-Tsuda, E Szomolanyi-Tsuda, E Szomolanyi-Tsuda, EA Kurt-Jones, EA Leadbetter, ES Shang, F Martin, F Martin, F Martin, G Muller, GB Lesinski, H Toyama, HC Selinka, I Scher, IC MacLennan, J Andersson, J Chinen, J Couderc, JA Gebbia, JC Garcia-Monco, JD Thomas, JR Hiernaux, JW Tung, K Takeda, KM Ansel, KM Haas, KM Toellner, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, KR Alugupalli, L Knoops, LJ McHeyzer-Williams, M Balasz, M Boes, M Muramatsu, M Schnare, M Yokota, MA Breukels, MC Hsu, MG McHeyzer-Williams, MS Cabatingan, N Maizels, N Maizels, N Watanabe, NL Bernasconi, NW Schroder, P Dullforce, PM Southern Jr, PW Yu, Q Vos, R Berland, R Guinamard, R Malley, RB Corley, RH Carter, RH Carter, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RL Chelvarajan, RM Zinkernagel, RT Woodland, RT Woodland, S Bondada, S Fagarasan, S Kruetzmann, S Weller, SA Ha, SE Connolly, SE Connolly, SH Feng, SR Yan, SR Yan, T Fehr, T Kawai, T Mizuno, T Mizuno, TL Carvalho, TT Wang, TV Obukhanych, UC Tornberg, UE Hopken, W Ellmeier, WN Khan, WN Khan, Y Arimitsu, Y Chong, Y Nagai   +123 more
core   +2 more sources

X-linked agammaglobulinemia with bronchiectasis and infection： a case report [PDF]

Zhenduanxue lilun yu shijian
X-linked agammaglobulinemia (XLA) is a rare disease characterized by severe hypogammaglobulinemia, antibody deficiency, and recurrent infections. This study reports a case of X-linked agammaglobulinemia combined with bronchiectasis and infection.
LIN Jiayuan, CHENG Qijian, CHEN Ling
doaj   +1 more source

Condiciones sistémicas asociadas con periodontitis en la infancia y la adolescencia: una revisión de las posibilidades diagnósticas [PDF]

, 2005
El término periodontitis se usa para describir un grupo de enfermedades multifactoriales que llevan a la destrucción progresiva de las estructuras que unen los dientes a los maxilares, el llamado aparato de soporte, que incluye el ligamento periodontal ...
Korostoff, Jonathan, Pinto, Andrés, Sollecito, Thomas P., Stewart, Jeffrey, Sullivan, Kathleen E.   +4 more
core   +1 more source

Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia

Journal of Infection, 2021
M. Dong, M. Luo, Aihua Li, Hui Xie, C. Gong, Juan Du, Xinrui Wang, Maozhong Li, Xue Wang, Yiting Wang, Haiyan Zhang, Xiaoxing Yang, Wei Cai, Hongjun Li, Wenzeng Zhang, Lijun Ren, Qingbin Lu, Fang Huang   +17 more
semanticscholar   +1 more source