Results 221 to 230 of about 11,478 (246)
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Clinical Reviews in Allergy & Immunology, 2000
The identification of the gene responsible for XLA has made it possible to clarify the clinical and laboratory findings in this disorder. It has markedly improved our ability to provide informative genetic counseling for affected families and it has helped unmask disorders that are clinically similar to XLA but genotypically different.
Jurg Rohrer +2 more
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The identification of the gene responsible for XLA has made it possible to clarify the clinical and laboratory findings in this disorder. It has markedly improved our ability to provide informative genetic counseling for affected families and it has helped unmask disorders that are clinically similar to XLA but genotypically different.
Jurg Rohrer +2 more
openaire +3 more sources
The Journal of Pediatrics, 1957
Summary A case of agammaglobulinemia in a 5 1/2-year-old boy is presented. The gamma globulin level in the child's serum as determined by immunological method was extremely low, between 0.5 and 1 mg. per 100 ml. plasma, which is lower than in other cases reported in the literature.
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Summary A case of agammaglobulinemia in a 5 1/2-year-old boy is presented. The gamma globulin level in the child's serum as determined by immunological method was extremely low, between 0.5 and 1 mg. per 100 ml. plasma, which is lower than in other cases reported in the literature.
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SUCCESSFUL HOMOGRAFT OF SKIN IN A CHILD WITH AGAMMAGLOBULINEMIA
Journal of the American Medical Association, 1955A substantial obstacle to current medical and surgical progress is the established fact that tissues and organs from one person transplanted to another will not survive. Although it has been suspected that rejection of homografts has an immunologic basis, proof of this concept is lacking.
Robert A. Good, Richard L. Vareo
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Agammaglobulinemia with polyarthritis and subcutaneous nodules [PDF]
The American Journal of Medicine, 1970 Abstract A case of agammaglobulinemia associated with polyarthritis and cutaneous nodules in a four year old boy is presented. Following extensive clinical, pathologic and serologic studies it was concluded that (1) the role of locally produced antibodies capable of complement fixation could not be excluded in the pathogenesis of the synovitis; (2 ...
Alan Winkelstein +2 more
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Chest Disease in Patients with Agammaglobulinemia
Diseases of the Chest, 19561. Agammaglobulinemia—a relatively new disease is discussed from the standpoint of the chest physician. 2. Eight cases studied at the University of Minnesota during the past two years are briefly presented. 3. The available literature on agammaglobulinemia is reviewed to emphasize the importance of pulmonary manifestations in the clinical ...
Robert A. Good, William F. Mazzitello
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Neutropenia in X-Linked Agammaglobulinemia
Clinical Immunology and Immunopathology, 1996X-linked agammaglobulinemia (XLA) is usually considered a disorder of B cell development; however, the gene that is defective in XLA encodes a cytoplasmic tyrosine kinase called Btk, that is expressed throughout myeloid as well as B cell differentiation. A review of medical records of patients in whom mutations in Btk had been identified indicated that
Jason E. Farrar +4 more
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Assessing Inheritance of Agammaglobulinemia
New England Journal of Medicine, 1994In the 42 years since Ogden Bruton discovered agammaglobulinemia,1 more than 50 additional immunodeficiency syndromes have been described2.
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The clinical spectrum of bruton’s agammaglobulinemia
Current Allergy and Asthma Reports, 2001X-linked, or Bruton's, agammaglobulinemia (XLA) was described in 1952 as the congenital inability to form antibodies. Patients were typically infants or young children with recurrent, severe bacterial infections. Other, milder cases of hypogammaglobulinemia were considered "acquired," and often presented later in life.
D M Stewart, D L Nelson, L Lian
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Paralytic poliomyelitis in a child with agammaglobulinemia
European Journal of Pediatrics, 1979This paper gives the clinical, immunological and virological data on a patient with agammaglobulinemia who developed paralytic poliomyelitis. The patient was a 3 year-old boy who had a typical B-cell defect without a T-cell defect. He had profound hypogammaglobulinemia and defective plasma cells and had repeated pyogenic infections which were ...
Tooru Nakao +5 more
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Immunology and Allergy Clinics of North America, 2001
B-lymphocyte development is essential for production of functional antibody and humoral immune responses. The mechanisms that regulate this process are complex and tightly regulated. Defects in nonredundant components of this pathway lead to a clinical and immunologic syndrome of congenital agammaglobulinemia with absence of B-cell development.
Hubert B. Gaspar, Christine Kinnon
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B-lymphocyte development is essential for production of functional antibody and humoral immune responses. The mechanisms that regulate this process are complex and tightly regulated. Defects in nonredundant components of this pathway lead to a clinical and immunologic syndrome of congenital agammaglobulinemia with absence of B-cell development.
Hubert B. Gaspar, Christine Kinnon
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