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Immunology and Allergy Clinics of North America, 2001
B-lymphocyte development is essential for production of functional antibody and humoral immune responses. The mechanisms that regulate this process are complex and tightly regulated. Defects in nonredundant components of this pathway lead to a clinical and immunologic syndrome of congenital agammaglobulinemia with absence of B-cell development.
Hubert B. Gaspar, Christine Kinnon
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B-lymphocyte development is essential for production of functional antibody and humoral immune responses. The mechanisms that regulate this process are complex and tightly regulated. Defects in nonredundant components of this pathway lead to a clinical and immunologic syndrome of congenital agammaglobulinemia with absence of B-cell development.
Hubert B. Gaspar, Christine Kinnon
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Assessing Inheritance of Agammaglobulinemia
New England Journal of Medicine, 1994In the 42 years since Ogden Bruton discovered agammaglobulinemia,1 more than 50 additional immunodeficiency syndromes have been described2.
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Paralytic poliomyelitis in a child with agammaglobulinemia
European Journal of Pediatrics, 1979This paper gives the clinical, immunological and virological data on a patient with agammaglobulinemia who developed paralytic poliomyelitis. The patient was a 3 year-old boy who had a typical B-cell defect without a T-cell defect. He had profound hypogammaglobulinemia and defective plasma cells and had repeated pyogenic infections which were ...
Tooru Nakao +5 more
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Pediatric Transplantation, 2019
X‐linked agammaglobulinemia (XLA) is a primary antibody disorder due to a mutation in the Bruton tyrosine kinase gene that requires lifelong immunoglobulin replacement resulting in a significant economic burden and treatment abandonment.
V. Vellaichamy Swaminathan +7 more
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X‐linked agammaglobulinemia (XLA) is a primary antibody disorder due to a mutation in the Bruton tyrosine kinase gene that requires lifelong immunoglobulin replacement resulting in a significant economic burden and treatment abandonment.
V. Vellaichamy Swaminathan +7 more
semanticscholar +1 more source
AGAMMAGLOBULINEMIA AND CHRONIC LYMPHOCYTIC LEUKEMIA
Annals of Internal Medicine, 1956Excerpt Many reports on agammaglobulinemia have appeared in the medical literature since 1952,1-24but there is only one report of two patients with this disease in association with chronic lymphocy...
Edward H. Reinhard, Robert T.S. Jim
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Agammaglobulinemia with Bronchopulmonary Manifestations
Diseases of the Chest, 1965The liver function test< werr as follows: the R. s.. an ~~~~~~i~~ of japanesP decmt. 25 thymol test was negative; nega1it.e cephalin Amyean OI~, entered the hospital A,,PS~. 1962, in ~ulation test; Congo red retention test: 40 per comatore a meningitis qndrome. cent.
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TCF3 Dominant Negative Variant Causes an Early Block in B-Lymphopoiesis and Agammaglobulinemia
Journal of Clinical Immunology, 2021Ebtehal Al Sheikh +4 more
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Current Spectrum of Infections in Patients with X-Linked Agammaglobulinemia
Journal of Clinical Immunology, 2021O. Paccoud +12 more
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