Results 61 to 70 of about 18,303,252 (310)

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

Neurobiology of Disease, 2018
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required for ...
Maria B. Goncalves, Yue Wu, Diogo Trigo, Earl Clarke, Tony Malmqvist, John Grist, Carl Hobbs, Thomas P. Carlstedt, Jonathan P.T. Corcoran   +8 more
doaj   +1 more source

Age-related atrial fibrosis [PDF]

AGE, 2008
Many age-related diseases are associated with, and may be promoted by, cardiac fibrosis. Transforming growth factor (TGF)-beta, hypoxia-induced factor (HIF), and the matrix metalloproteinase (MMP) system have been implicated in fibrogenesis. Thus, we investigated whether age is related to these systems and to atrial fibrosis.
Gramley, F, Lorenzen, J, Knackstedt, C, Rana, O, Saygili, E, Frechen, D, Stanzel, S, Pezzella, F, Koellensperger, E, Weiss, C, Münzel, T, Schauerte, P   +11 more
openaire   +3 more sources

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury

Fluids and Barriers of the CNS
Background After a spinal cord injury (SCI), disruption of the blood-spinal cord barrier (BSCB) leads to secondary injuries, including inflammatory responses and apoptotic cell death, ultimately causing permanent neurological deficits.
Chan Sol Park, Jee Youn Lee, Tae Young Yune   +2 more
doaj   +1 more source

Mirror proteorhodopsins

Communications Chemistry, 2023
Proteorhodopsins (PRs), bacterial light-driven outward proton pumps comprise the first discovered and largest family of rhodopsins, they play a significant role in life on the Earth.
Ivan S. Okhrimenko, Kirill Kovalev, Lada E. Petrovskaya, Nikolay S. Ilyinsky, Alexey A. Alekseev, Egor Marin, Tatyana I. Rokitskaya, Yuri N. Antonenko, Sergey A. Siletsky, Petr A. Popov, Yuliya A. Zagryadskaya, Dmytro V. Soloviov, Igor V. Chizhov, Dmitrii V. Zabelskii, Yury L. Ryzhykau, Alexey V. Vlasov, Alexander I. Kuklin, Andrey O. Bogorodskiy, Anatolii E. Mikhailov, Daniil V. Sidorov, Siarhei Bukhalovich, Fedor Tsybrov, Sergey Bukhdruker, Anastasiia D. Vlasova, Valentin I. Borshchevskiy, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Ernst Bamberg, Valentin I. Gordeliy   +28 more
doaj   +1 more source

Glare recovery in age related maculopathy [PDF]

, 1987
This study has investigated the dynamics of the glare recovery process in a group of subjects with age related maculopathy (ARM) and pre-aqe related maculopathy (PARM), and compared the results of these groups with a group of age-matched controls.
Collins, Michael J.
core  

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Delirium prevalence and incidence in acutely admitted older patients: an observational cohort study

BMC Geriatrics
Background Delirium is common in acutely ill older adults and is associated with multiple unfavourable outcomes, including an increased risk of dementia and death.
Mathias Nikolai Petersen Hella, Hogne Soennesyn, Hanne Brit Hetland, Audun Osland Vik-Mo, Ane Djuv, Anita Sunde, Rune Tord Wathne Oftedal, Leiv Otto Watne, Dag Aarsland, Anne Katrine Bergland   +9 more
doaj   +1 more source

Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model

Biological Research, 2023
Background/aims Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection.
Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao, Xiaotang Ma   +8 more
doaj   +1 more source

Age-related macular degeneration

Survey of Ophthalmology, 1988
Age-related macular degeneration (AMD) is the leading cause of irreversible severe visual loss in the United States in people over 50 years of age. The nonexudative stage includes hard drusen (associated with localized dysfunction of the retinal pigment epithelium [RPE]), soft drusen (associated with diffuse dysfunction of the RPE), and geographic ...
N M, Bressler, S B, Bressler, S L, Fine
openaire   +2 more sources