Results 91 to 100 of about 126,431 (255)
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
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Minnesota medicine, 2008 Age-related hearing loss or presbycusis is hearing loss that progressively worsens with age. With the expected increase in the number of elderly in the United States, the problem is anticipated to be increasingly common, and the impact widely felt in coming years. This article discusses the causes and mechanisms of this type of hearing loss and current
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The role of cochlea extracellular matrix in age related hearing loss
Клинический разбор в общей медицинеAge-related hearing loss (ARHL) is a common condition among the elderly. Extracellular matrix (ECM) is an important cell-free structure of the body consisting of proteins such as collagen, proteoglycans and glycoproteins.
Mergen A. Dzhimgirov +1 more
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Annals of Neurology, EarlyView.Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate +34 more
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The Anatomical Record, EarlyView.Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
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Risk of mortality in the elderly with different degree of sensorineural hearing loss in Taiwan
Frontiers in NeurologyIntroductionSensorineural hearing loss (SNHL) may lead to disability in many aspects. This study aims to investigate the risk of mortality in the elderly with sensorineural hearing loss (SNHL) in Taiwan.MethodsThree hundred and eighteen subjects with ...
Jin-Cherng Chen +6 more
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Redescription of the Triassic cynodont Cistecynodon parvus and reassessment of its phylogeny
The Anatomical Record, EarlyView.Abstract Cynodontia is an important subclade of Therapsida that first occurred in the late Permian. It includes extinct subclades which are the non‐mammaliaform cynodonts and Mammaliaformes, with the latter ultimately giving rise to crown mammals. The systematics of non‐mammaliaform cynodonts has been extensively studied and is relatively well‐resolved,
Erin S. Lund +4 more
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Loss of Cisd2 Exacerbates the Progression of Age-Related Hearing Loss
Aging and diseaseAge-related hearing loss (ARHL) is a disease that impacts human quality of life and contributes to the progression of other neuronal problems. Various stressors induce an increase in free radicals, destroy mitochondria to further contribute to cellular malfunction, and compromise cell viability, ultimately leading to functional decline. Cisd2, a master
Chen, Hang-Kang +7 more
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Age-related hearing loss: biological aspects
BMC Geriatrics, 2010 Chiarella G, Cassandro E
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The Anatomical Record, EarlyView.Abstract Nineteenth century excavations of the Ciply‐Malogne Phosphatic Chalk Formation in Hainaut, Belgium, yielded over 50 partial mosasaur skeletons, the majority of which were referred to the species Mosasaurus lemonnieri Dollo, 1889. In the years since, this taxon has experienced a complicated taxonomic history, and its exceptional hypodigm has ...
Henry S. Sharpe +3 more
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