Results 91 to 100 of about 121,313 (254)

Aberrant Neural Entrainment to Word‐Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit

Autism Research, EarlyView.
ABSTRACT Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role in language acquisition.
Laura J. Batterink, Yanchen Liu, Grace Westerkamp, Jae Citarella, Peyton Siekierski, Lynxie Voorhees, Lauren E. Ethridge, Elizabeth Smith, Rana Elmaghraby, Craig A. Erickson, Zag ElSayed, Anubhuti Goel, Steve W. Wu, Ernest V. Pedapati   +13 more
wiley   +1 more source

The role of cochlea extracellular matrix in age related hearing loss

Клинический разбор в общей медицине
Age-related hearing loss (ARHL) is a common condition among the elderly. Extracellular matrix (ECM) is an important cell-free structure of the body consisting of proteins such as collagen, proteoglycans and glycoproteins.
Mergen A. Dzhimgirov, Alina F. Dzhimgirova   +1 more
doaj   +1 more source

The Effect of Online Parent Training With and Without Coaching Support on the Well‐Being of Families of Children With Neurodisabilities: A Randomized Controlled Trial

Autism Research, EarlyView.
ABSTRACT Families of children with neurodisabilities often face significant child behavioral challenges that can affect overall family functioning and well‐being. This randomized controlled trial (RCT) used family resilience theory as the investigative framework to examine the impact of an online parenting program designed to address child behavioral ...
Jeffrey McCrossin, Ali Filali‐Mouhim, Michael Ungar, Karen McEwan, Kathleen O'Grady, Donna Thomson, Parent Advisory Group, Patricia Lingley‐Pottie, Patrick McGrath, Lucyna M. Lach   +9 more
wiley   +1 more source

Risk of mortality in the elderly with different degree of sensorineural hearing loss in Taiwan

Frontiers in Neurology
IntroductionSensorineural hearing loss (SNHL) may lead to disability in many aspects. This study aims to investigate the risk of mortality in the elderly with sensorineural hearing loss (SNHL) in Taiwan.MethodsThree hundred and eighteen subjects with ...
Jin-Cherng Chen, Jin-Cherng Chen, Pei-Shan Hsieh, Juen-Haur Hwang, Juen-Haur Hwang, Juen-Haur Hwang, Juen-Haur Hwang   +6 more
doaj   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Age-related hearing loss.

Minnesota medicine, 2008
Age-related hearing loss or presbycusis is hearing loss that progressively worsens with age. With the expected increase in the number of elderly in the United States, the problem is anticipated to be increasingly common, and the impact widely felt in coming years. This article discusses the causes and mechanisms of this type of hearing loss and current
openaire   +1 more source

Loss of Cisd2 Exacerbates the Progression of Age-Related Hearing Loss

Aging and disease
Age-related hearing loss (ARHL) is a disease that impacts human quality of life and contributes to the progression of other neuronal problems. Various stressors induce an increase in free radicals, destroy mitochondria to further contribute to cellular malfunction, and compromise cell viability, ultimately leading to functional decline. Cisd2, a master
Chen, Hang-Kang, Wang, Yen-Hsin, Lei, Cing-Syuan, Guo, Yu-Ru, Tang, Ming-Chi, Tsai, Ting-Fen, Chen, Yi-Fan, Wang, Chih-Hung   +7 more
openaire   +2 more sources

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Age-related hearing loss: biological aspects

BMC Geriatrics, 2010
Chiarella G, Cassandro E
doaj   +2 more sources

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source