Results 91 to 100 of about 205,027 (361)

Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing [PDF]

, 2011
Background/aims: With the increased efficacy of current therapy for wet age-related macular degeneration (AMD), better ways to detect wet AMD are needed.
Bababeygy, Simon R., Fink, Wolfgang, Jivrajka, Renu V., Robison, Craig D., Sadun, Alfredo A., Sebag, J.   +5 more
core   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Retinitis Pigmentosa‐Associated Gene TRIM49 Regulates ULK1‐Mediated Autophagy and Photoreceptor Phagocytosis by the Retinal Pigment Epithelium

Advanced Science, EarlyView.
Based on next‐generation sequencing data of retinitis pigmentosa (RP) patients and controls, this study identifies TRIM49 as a novel gene for autosomal recessive RP. TRIM49 is specifically expressed in the retinal pigment epithelium (RPE) of human retina.
Zhen Yi, Chaojuan Wen, Han Du, Yingwei Wang, Shuowei Chen, Jie Liu, Shuhan Zhang, Junwen Wang, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Yi Jiang, Jiamin Ouyang, Panfeng Wang, James Fielding Hejtmancik, Wenmin Sun, Huangxuan Shen, Qingjiong Zhang   +17 more
wiley   +1 more source

Association of age related macular degeneration and age related hearing impairment

Journal of Ophthalmic & Vision Research, 2016
Purpose: To evaluate the association between age-related macular degeneration (ARMD) and sensory neural hearing impairment (SHI). Methods: In this case-control study, hearing status of 46 consecutive patients with ARMD were compared with 46 age-matched ...
Hassan Ghasemi, Malihe Shahidi Pourakbari, Morteza Entezari, Mohammad Ebrahim Yarmohammadi   +3 more
doaj   +1 more source

An Evaluation of a Battery of Functional and Structural Tests as Predictors of Likely Risk of Progression of Age-Related Macular Degeneration. [PDF]

, 2018
Purpose: To evaluate the ability of visual function and structural tests to identify the likely risk of progression from early/intermediate to advanced AMD, using the Age-Related Eye Disease Study (AREDS) simplified scale as a surrogate for risk of ...
Bailey, C., Binns, A. M., Margrain, T. H., Robinson, D. G.   +3 more
core   +3 more sources

Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology

Advanced Intelligent Systems, EarlyView.
This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin, Lei Wang, Shanjun Wu, Jiewei Jiang, Wei Qiang, Yangyang Wang, Shihong Wang, Yi Shao, Wei Chen, Zhongwen Li   +9 more
wiley   +1 more source

Age- and sex-based evaluation of the association between refractive error and age-related macular degeneration in the Korean population.

PLoS ONE, 2020
PURPOSE:The aim of this study was to investigate the association between refractive error and prevalence of age-related macular degeneration (AMD) in Korean adults, based on the sex and age group.
Kook Lee, Jin-Woo Kwon, Wan Jin Jahng, Young-Hoon Park, Donghyun Jee   +4 more
doaj   +1 more source

Recent Advances in Age-Related Macular Degeneration Therapies

Molecules, 2022
Age-related macular degeneration (AMD) was described for the first time in the 1840s and is currently the leading cause of blindness for patients over 65 years in Western Countries. This disease impacts the eye’s posterior segment and damages the macula,
Marie Fabre, L. Mateo, Diana Lamaa, S. Baillif, Gilles Pagès, Luc Demange, C. Ronco, R. Benhida   +7 more
semanticscholar   +1 more source

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye [PDF]

, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Al Hosaini, H, Bird, AC, Jeffery, G, Lengyel, I, Luthert, P, Tufail, A   +5 more
core   +1 more source

Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches

International Journal of Molecular Sciences, 2020
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive retinal degenerative disease of the macula that affects elderly people and cause central vision impairment.
F. Ricci, F. Bandello, P. Navarra, G. Staurenghi, M. Stumpp, M. Zarbin   +5 more
semanticscholar   +1 more source