Results 21 to 30 of about 93,339 (287)

Age-related macular degeneration: an overview

Revista Brasileira de Oftalmologia, 2021
Age-related macular degeneration is the most important cause of irreversible vision loss in the elderly and has been considered a severe public health problem. Current treatments have only been successful in delaying the loss of central vision.
Rogil José de Almeida Torres, Ana Lúcia dos Anjos Ferreira   +1 more
doaj   +1 more source

The estimated prevalence and incidence of late stage age related macular degeneration in the UK [PDF]

, 2012
BACKGROUND: UK estimates of age related macular degeneration (AMD) occurrence vary. AIMS: To estimate prevalence, number and incidence of AMD by type in the UK population aged ≥50 years.
Fletcher, AE, Owen, CG, Rudnicka, AR, Fletcher, Astrid E, Rudnicka, Alicja R, Jarrar, Z, Cook, DG, Wormald, Richard, Wormald, R, Owen, Christopher G, Jarrar, Zakariya, Cook, Derek G   +11 more
core   +1 more source

Open innovation in neuroscience research and drug discovery

Brain and Neuroscience Advances, 2018
The pressures on the pharmaceutical industry have incentivised a number of new collaborative models of research and development which can be categorised as open innovation.
Ann J. Hunter, Wen H. Lee, Chas Bountra
doaj   +1 more source

Macular Pigment Optical Density and its Determinants among Adults: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Interplay exists between the risk factors of Agerelated Macular Degeneration (AMD) and the factors influencing Macular Pigment Optical Density (MPOD) level.
POOJA GOYAL, MITASHA SINGH, SHASHI VASHISHTH, SATISH JAYERIA   +3 more
doaj   +1 more source

Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]

, 2013
BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Peto, Tunde; id_orcid, Bastawrous, Andrew, Andrew Bastawrous, Foster, Allen, Kuper Hannah, Allen Foster, Tunde Peto, Hannah Kuper, Tunde Peto (295260), Leung Irene, Irene Leung (336330), Leung, Irene, Wanjiku Mathenge (336328), Bastawrous Andrew, Andrew Bastawrous (336329), Peto Tunde, Hannah Kuper (25751), Wanjiku Mathenge, Allen Foster (94749), Peto, Tunde, Kuper, Hannah, Mathenge Wanjiku, Irene Leung, Mathenge, Wanjiku, Foster Allen   +24 more
core   +1 more source

Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study. [PDF]

PLoS ONE, 2015
Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging evidence suggests that osteoarthritis has a chronic inflammatory component to its pathogenesis similar to age-related ...
Elaine W Chong, Yuanyuan Wang, Liubov D Robman, Khin Zaw Aung, Galina A Makeyeva, Graham G Giles, Stephen Graves, Flavia M Cicuttini, Robyn H Guymer   +8 more
doaj   +1 more source

Candidate gene study of macular response to supplemental lutein and zeaxanthin. [PDF]

, 2013
Supplementation with carotenoids is proposed to protect against age-related macular degeneration. There is, however, considerable variability in retinal macular pigment response, which may be due to underlying genetic variation. The purpose of this study
Liew, SH Melissa, Venturini, Cristina, Williams, Katherine; id_orcid, Beatty, Stephen, Hysi, Pirro G., Williams, Katie M., Gilbert, Clare E, Gilbert, Clare E., Hysi, Pirro G, Williams, Katie M, Nag, Abhishek, Hammond, Christopher J., Liew, S.H. Melissa, Yonova-Doing, Ekaterina, Hammond, Christopher J, Liew, S H Melissa   +15 more
core   +1 more source

Novel rodent models for macular research [PDF]

, 2010
BACKGROUND: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Gesine Huber, Muehlfriedel, Regine, Huber, G., Feng, Yuxi, Seeliger, M., Tanimoto, Naoyuki, Tanimoto Naoyuki, Severin Heynen, Hans-Peter Hammes, Christian Grimm, Feng, Y., Imsand Coni, Imsand, Coni, Muehlfriedel Regine, Susanne C. Beck, Huber, Gesine, Heynen, S., Grimm Christian, Regine Muehlfriedel, Huber Gesine, vom Hagen Franziska, Coni Imsand, Imsand, C., Seeliger Mathias W., Mühlfriedel, R., Peichl, Leo, Mathias W Seeliger, vom Hagen, F., Mühlfriedel, Regine, Tanimoto, N., Heynen Severin, Hammes, Hans-Peter, Seeliger, Mathias W, Beck Susanne C., Seeliger, Mathias W., Peichl Leo, Yuxi Feng, Peichl, L., Beck, Susanne C; https://orcid.org/, Grimm, C., Feng Yuxi, Mathias W. Seeliger, Leo Peichl, Franziska vom Hagen, Grimm, Christian, Grimm, Christian; https://orcid.org/, vom Hagen, Franziska, Beck, S., Beck, Susanne Christiane, Hammes Hans-Peter, Susanne C Beck, Naoyuki Tanimoto, Hammes, H., Heynen, Severin   +53 more
core   +1 more source

Intravitreal aflibercept in neovascular age-related macular degeneration previously treated with ranibizumab

International Journal of Ophthalmology, 2017
AIM: To report the change in visual acuity and central macular thickness (CMT) following treatment with intravitreal aflibercept injections in patients with neovascular age-related macular degeneration (nAMD) with suboptimum response to ranibizumab ...
Rachel Hui Fen Lim, Bhaskar Gupta, Peter Simcock   +2 more
doaj   +1 more source

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Cells, 2023
Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD).
Adnan H. Khan, Itay Chowers, Andrew J. Lotery   +2 more
doaj   +1 more source