Results 181 to 190 of about 7,367,025 (250)

Beyond a universal obesity microbiome signature: pre-intervention heterogeneity and a framework for baseline profiling. [PDF]

Front Nutr
Liu P, Mao R, Li N, Guo J, Wang J, Mao J.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Association Between Smartphone Application Diversity and Occupational Participation Among Community-Dwelling Older Adults: A Cross-Sectional Study. [PDF]

Scand J Occup Ther
Shimokihara S, Yokoyama K, Ihira H, Matsuzaki-Kihara Y, Mizumoto A, Tashiro H, Saito H, Makino K, Katsuura S, Kobayashi M, Shimada K, Yama K, Miyajima R, Sasaki T, Ikeda N.   +14 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Characteristics of gut microbiota in children with language developmental delay. [PDF]

Front Pediatr
Li Y, Wang S, Xu H, Nie X, Zhao D, Zhu W, Zhu R.   +6 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Age-related changes in the gut microbiota of a long-lived seabird suggest divergence from mammalian models. [PDF]

R Soc Open Sci
Hanski E, Bates K, Hughes R, Newell M, Penn A, Raulo A, Scott L, Tang L, Fayet AL.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

How Mixed Are Production-Oriented Planted Forests? A Global Review and Classification Approach. [PDF]

Glob Chang Biol
Cagnoni LB, Weih M, Adler A, Guillemot J, Brancalion PHS.   +4 more
europepmc   +1 more source