Results 91 to 100 of about 50,476,256 (254)

Determinants of Age at Menarche in the Newcastle Thousand Families Study [PDF]

, 2005
Early life determinants of age at menarche were investigated for female participants in the longitudinal Thousand Families Study based in Newcastle upon Tyne.
Blell, Mwenza T.
core  

How material wealth influences age at first birth among Pimbwe women from Tanzania

Evolutionary Human Sciences
Whether a woman has an early or late age at first birth may be influenced by the amount of her wealth and/or its variability. Theory predicts that women tend to delay their first birth when they have high levels of material wealth, and reproduce earlier ...
Pablo José Varas Enríquez, Riana Minocher, Dieter Lukas, Heidi Colleran, Monique Borgerhoff Mulder   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Regularities and peculiarities of birth schedules in industrialized countries: an analysis of FFS data [PDF]

Inter-individual diversity of women according to birth numbers (quantum) and birth spacing (tempo) are important for understanding of fertility regimes. Elsewhere, we have shown that diversity with respect to fertility quantum is increasing from older to
René Houle, Vladimir M. Shkolnikov
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPrevious studies observe associations between lifetime parity and cardiovascular disease, but relatively fewer investigate age at first childbirth (AFB).
Nicole T. A. Rosendaal, Beatriz Alvarado, Yan Yan Wu, Maria P. Velez, Saionara M. Aires da Câmara, Catherine M. Pirkle   +5 more
doaj   +1 more source

Age at first birth and women's midlife health: Cohort and race differences across the 20th century. [PDF]

Soc Sci Med, 2023
Wolfe JD, Thomeer MB, Reczek R.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Fertility Postponement and Regional Patterns of Dispersion in Age at First Birth: Descriptive Findings and Interpretations

Comparative Population Studies, 2019
Previous studies have documented an increasing heterogeneity in first-birth timing in countries experiencing the postponement transition. Sobotka (2004), for instance, showed a rising dispersion in age at first birth in developed countries, particularly ...
Mathías Nathan, Ignacio Pardo
doaj