Results 101 to 110 of about 50,476,256 (254)

A contemporary issue in demography: The rising age at first birth, pros and cons

Acta Universitatis Carolinae Geographica, 2016
Two decades after Aleš Hrdlička’s death the introduction of effective contraceptives broke the evolutionary link between sexuality and procreation. Since then we decide about having children or not, and if we want them we can also decide about their ...
Gijs Beets
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Average age at birth for grandmothers.

, 2018
Solid lines represent average age at first grandchild birth, and dashed for average age at the birth of any grandchild. Maternal grandmothers are represented by lines within blue 95% confidence intervals, and paternal grandmothers by lines within orange ...
Simon N. Chapman (2551879), Jenni E. Pettay (31832), Virpi Lummaa (31835), Mirkka Lahdenperä (330902)   +3 more
core   +1 more source

Spatial distribution and predictors of early childbearing among Ethiopian women: evidence from the 2016 Ethiopian Demographic and Health Survey

BMC Pregnancy and Childbirth
Background Age at first birth is a crucial factor in understanding fertility patterns within a population. Ethiopia reports high rates of maternal and child mortality alongside elevated fertility levels.
Amare Teshome Tefera, Fanuel Gashaw, Martha Solomon, Nebiyu Bekele, Shegaye Shumet, Tigist Mulugeta, Araya Mesfin Nigatu, Solomon Gedlu Nigatu   +7 more
doaj   +1 more source

Correlates of age at first birth among women in Ethiopia: use of multilevel survival analysis models. [PDF]

Pan Afr Med J, 2023
Muluneh EK, Alemu M.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Determinants of children ever born among women in Somalia: a national survey study

Archives of Public Health
Background Fertility rates in Somalia are among the highest globally, posing significant challenges to maternal and child health and sustainable development. However, there is limited evidence regarding the specific drivers of high fertility.
Mohamed Mustaf Ahmed, Mohamed Abdirahim Omar, Yahye Sheikh Abdulle Hassan, Abdirasak Sharif Ali   +3 more
doaj   +1 more source

Associations of age at first birth and lifetime parity with weight and adiposity across midlife in women from Project Viva. [PDF]

Obesity (Silver Spring), 2023
Soria-Contreras DC, Aris IM, Rifas-Shiman SL, Perng W, Hivert MF, Chavarro JE, Oken E.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source