Results 111 to 120 of about 50,476,256 (254)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Age at first birth and risk of urinary incontinence after delivery: a dose-response meta-analysis. [PDF]
Sci Rep, 2022 Ren Y +6 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The Ongoing Transformation of Family and Reproductive Behaviour in Bratislava and Its Hinterland
DemografieThe transformation of family and reproductive behaviour in Slovakia has significantly impacted not only the population of the largest cities since the 1990s and has also gradually given rise to key changes in smaller towns and rural municipalities ...
Branislav Šprocha
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Income Profile of Non-College Women by Age at First Birth (1995–2009).
, 2016 Income Profile of Non-College Women by Age at First Birth (1995–2009).
Fane Groes (847622) +2 more
core +1 more source
Acta PsychologicaBackground: In recent years, the age at first birth in China has continued to rise, yet the traditional ideal of having both sons and daughters (child gender diversity) remains deeply ingrained.
Zhong Fei, Yue Wang
doaj +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Does Parents' Age at First Birth Moderate Intergenerational Continuity in Early-Onset Cannabis Use? [PDF]
J Stud Alcohol Drugs, 2021 Henry KL +6 more
europepmc +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source