Results 101 to 110 of about 9,169,898 (343)

Relationship of age to outcome and clinicopathologic findings in men submitted to radical prostatectomy

open access: yesInternational Brazilian Journal of Urology, 2005
OBJECTIVE: It is controversial whether age is associated with higher grade and worse outcome. Some studies have not found age to be related to outcome nor younger age to be associated with better response to therapy.
Athanase Billis   +8 more
doaj   +1 more source

Preceptor tips for navigating generational differences with introductory and advanced pharmacy practice experience students

open access: yesPharmacy Practice, 2020
Ideally, precepting during introductory and advanced pharmacy practice experiences should be tailored to meet the individualized needs of learners. Understanding generational similarities and differences that exist between both learners and educators ...
Melinda J. Burnworth   +3 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia

open access: yesFrontiers in Aging Neuroscience
BackgroundObjective biomarkers to differentiate trigeminal neuralgia (TN) subtypes are lacking. This study aimed to evaluate the utility of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) for distinguishing primary TN from
Zihao Zhang   +8 more
doaj   +1 more source

Factors Associated With Retinal Vessel Diameters in an Elderly Population: the Thessaloniki Eye Study [PDF]

open access: yes, 2019
Purpose: To identify the factors associated with retinal vessel diameters in the population of the Thessaloniki Eye Study. Methods: Cross-sectional population-based study (age ≥ 60 years). Subjects with glaucoma, late age-related macular degeneration,
Anastasopoulos, Eleftherios   +9 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Motor Vehicle Usage Patterns in Australia: A Comparative Analysis of Driver, Vehicle & Purpose Characteristics for Household & Freight Travel [PDF]

open access: yes, 2003
An ordered probit model is used to predict motor vehicle usage in Australia on the basis of the unit record files underlying the Australian Bureau of Statistics’ Survey of Motor Vehicle Use. Both household and freight transport are analysed.
Goffey, Kathleen, Worthington, Andrew
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

The relationship between BRCA-associated breast cancer and age factors: an analysis of the Japanese HBOC consortium database. [PDF]

open access: yesJ Hum Genet, 2021
Okano M   +9 more
europepmc   +1 more source

Cross-cultural comparison of genetic and cultural transmission of smoking initiation using an extended twin kinship model [PDF]

open access: yes, 2018
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior.
Eaves, Lindon J   +6 more
core   +2 more sources

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