Results 111 to 120 of about 2,514,827 (314)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of Outcomes in Pancreaticoduodenectomy for Elderly Patients Aged 80 and Above: A Retrospective Study Using Inverse Probability of Treatment Weighting

Aging Medicine
Objectives With an aging population, more elderly individuals are facing the decision to undergo complex surgeries, such as pancreaticoduodenectomy (PD). This study evaluates the safety and feasibility of PD in patients aged 80 and above.
Tianxiao Wang, Yue Qiu, Yingjixing Luo, Ruili Wei, Li Xu, Jia Huang, Wenying Zhou, Hanchun Huang, Yongliang Sun, Zhiying Yang   +9 more
doaj   +1 more source

Sex differences in aged 80 and over hospitalized patients with community-acquired UTI: A prospective observational study. [PDF]

Heliyon, 2022
López-Cruz I, Esparcia A, Madrazo M, Alberola J, Eiros JM, Artero A.   +5 more
europepmc   +1 more source

Income and Poverty Among Older Americans in 2008 [PDF]

, 2007
[Excerpt] Older Americans are an economically diverse group. In 2008, the median income of individuals aged 65 and older was $18,208 but incomes varied widely around this average.
Purcell, Patrick
core   +6 more sources

Late diagnosis among our ageing HIV population: a cohort study [PDF]

, 2014
INTRODUCTION: With the advent of combined antiretroviral therapy (cART), more people infected with HIV are living into older age; 22% of adults receiving care in the UK are aged over 50 years [1].
Bodley-Tickell, Delpech, James Coultas, Lisa Goodall, Neena Bodasing, Sarah Mensforth   +5 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes-Six Pandemic Waves: OCTA-COVID Study. [PDF]

Int J Environ Res Public Health, 2022
Ruiz-Huerta C, Canto MV, Ruiz C, González I, Lozano-Montoya I, Quezada-Feijoo M, Gómez-Pavón FJ.   +6 more
europepmc   +1 more source

Older people’s experiences of informal care in rural Flanders, Belgium [PDF]

, 2019
Flanders (Belgium) is ageing at high speed. The number of people aged over 80 will increase from more than 400.000 today to nearly 800.000 in 2060, which is 10 % of the population. Although the entire region is ageing, older people are overrepresented in
De Decker, Pascal, Schillebeeckx, Elise, Volckaert, Emma   +2 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Comparison of Radical Cystectomy with Conservative Treatment in Geriatric ( 80) Patients with Muscle-Invasive Bladder Cancer

International Brazilian Journal of Urology, 2013
Introduction The aim of this study was to compare overall survival in elderly patients (≥ 80 years) with muscle-invasive bladder cancer (MIBC) undergoing either radical cystectomy (RC) or conservative treatment.
Thomas Martini, Roman Mayr, Clemens Wehrberger, Christopher Dechet, Michele Lodde, Salvatore Palermo, Emanuela Trenti, Evi Comploj, Armin Pycha   +8 more
doaj   +1 more source