Results 101 to 110 of about 1,421,492 (241)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Respiratory function and its predictive value for adverse health outcomes in adults aged 80 and over

, 2017
This thesis investigates the predictive value of respiratory function for adverse health outcomes in adults aged 80 and over, the fastest growing age-group worldwide. Using the dataset of BELFRAIL, a population-based, prospective cohort of adults aged 80
Hegendörfer, Eralda
core  

The impact and effectiveness of pneumococcal vaccination in Scotland for those aged 65 and over during winter 2003/2004 [PDF]

, 2008
Background: For winter 2003/2004 in Scotland, it was recommended that all those aged 65 and over be eligible to receive 23-valent polysaccharide pneumococcal vaccine (23vPPV), which has been shown to be effective in reducing the risk of invasive ...
Simpson, Colin R, Ahmed, S., Macfarlane, Tatania V., McMenamin, J., Weir, Amanda, Lewis D Ritchie, Mooney John D, McMenamin, Jim, Robertson, C., Weir, A.M., Jim McMenamin, Macfarlane, Tatania V, Ritchie Lewis D, Clarke, Stuart C., Clarke Stuart C, Simpson, Colin R., Mooney, John D., Robertson Chris, Tatania V Macfarlane, Amanda Weir, Syed Ahmed, Mooney, John D, Stuart C Clarke, Simpson, C.R., Chris Robertson, Ritchie, L.D., Mooney, J.D., Ahmed, Syed, Macfarlane Tatania V, Ritchie, Lewis D, McMenamin Jim, Weir Amanda, Clarke, Stuart C, Colin R Simpson, Clarke, S.C., Ahmed Syed, Robertson, Chris, Macfarlane, T.V., Ritchie, Lewis D., Simpson Colin R, John D Mooney, Ritchie, L.D, Macfarlane, T.V, Clarke, S.C, Weir, A, McMenamin, J, Robertson, C, Ahmed, S, Mooney, J.D, Simpson, C.R   +49 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cholecystectomy for gallbladder disease in elderly aged 80 years and over.

, 2009
BACKGROUND/AIMS: Patients aged 80 years and over show greater risk of complicated gallbladder diseases and associated comorbidities. The aim of the study is to evaluate the prognosis after laparoscopic or open cholecystectomy in these patients ...
PIETROLETTI, Renato, DE VITA F, SIMI M., LEARDI, Sergio   +3 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Erratum to: Evolution of the “fourth stage” of epidemiologic transition in people aged 80 years and over: population-based cohort study using electronic health records [PDF]

, 2017
Background In the “fourth stage” of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been reported.
Hazra, Nisha C., Gulliford, Martin, Martin Gulliford, Nisha C. Hazra   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source