Results 111 to 120 of about 3,499 (199)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
[The safety of anesthesia of patients operated at the age over 80].
Wiadomosci lekarskie (Warsaw, Poland : 1960), 1999 The authors present a retrospective evaluation of the safety of anaesthetizing patients who are above 80 years of age. The level of safety is raised by canal anaesthesia, complex treatment, proper monitoring and intensified perioperative care. In patients operated in emergency routine the coexistence of heart diseases and diabetes is a disadvantage ...
E, Podwińska +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
AN ANALYSIS OF OPERATION IN THE AGED PATIENTS OVER 80
The journal of the Japanese Practical Surgeon Society, 1987 OHKADO, Akihiko +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Abdominal Surgery in Patients Over Age 80
Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons), 1999 Hitoshi KOTANAGI +4 more
openaire +2 more sources
[Creutzfeldt-Jakob disease in a person over the age of 80].
Tijdschrift voor gerontologie en geriatrie, 2014 Creutzfeldt-Jakob disease is a rare neurodegenerative disease that can occur in four forms. The sporadic form, the familial form, the iatrogenic form and variant Creutzfeldt-Jakob disease. The sporadic form is seen in about 1 per million people per year and is associated with rapidly progressive cognitive decline, psychiatric and neurological symptoms.
E, Bliekendaal, L, Oudewortel
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source