Results 111 to 120 of about 1,250,574 (290)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Providing ambulatory healthcare for people aged 80 and over: Views and perspectives of physicians and dentists from a qualitative survey. [PDF]

PLoS One, 2022
Herrler A, Valerius L, Barbe AG, Vennedey V, Stock S.   +4 more
europepmc   +1 more source

Respiratory function and its predictive value for adverse health outcomes in adults aged 80 and over

, 2017
This thesis investigates the predictive value of respiratory function for adverse health outcomes in adults aged 80 and over, the fastest growing age-group worldwide. Using the dataset of BELFRAIL, a population-based, prospective cohort of adults aged 80
Hegendörfer, Eralda
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An overview on the treatment and outcome factors of ankle fractures in elderly men and women aged 80 and over: a systematic review. [PDF]

Arch Orthop Trauma Surg, 2022
van Halsema MS, Boers RAR, Leferink VJM.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Comparison of Radical Cystectomy with Conservative Treatment in Geriatric ( 80) Patients with Muscle-Invasive Bladder Cancer

International Brazilian Journal of Urology, 2013
Introduction The aim of this study was to compare overall survival in elderly patients (≥ 80 years) with muscle-invasive bladder cancer (MIBC) undergoing either radical cystectomy (RC) or conservative treatment.
Thomas Martini, Roman Mayr, Clemens Wehrberger, Christopher Dechet, Michele Lodde, Salvatore Palermo, Emanuela Trenti, Evi Comploj, Armin Pycha   +8 more
doaj   +1 more source

What matters to people aged 80 and over regarding ambulatory care? A systematic review and meta-synthesis of qualitative studies. [PDF]

Eur J Ageing, 2022
Herrler A, Kukla H, Vennedey V, Stock S.
europepmc   +1 more source

Social Class Differences in Secular Trends in Established Coronary Risk Factors over 20 Years: A Cohort Study of British Men from 1978-80 to 1998-2000 [PDF]

, 2011
Background: Coronary heart disease (CHD) mortality in the UK since the late 1970s has declined more markedly among higher socioeconomic groups. However, little is known about changes in coronary risk factors in different socioeconomic groups.
Morris, RW, Richard W. Morris, Hardoon, Sarah L, Whincup, PH, Wannamethee SG, Hardoon, SL, Sarah L Hardoon, Morris, Richard W, Lucy T Lennon, Lennon, Lucy T, Wannamethee S. G., Whincup Peter H., Sheena E Ramsay, Wannamethee, S G, Wannamethee, SG, Richard W Morris, Lennon Lucy T., Hardoon Sarah L., S G Wannamethee, Whincup, Peter H, Lucy T. Lennon, Lennon LT, Ramsay, Sheena E, Sarah L. Hardoon, Whincup PH, Peter H. Whincup, Morris Richard W., Ramsay SE, Hardoon SL, Ramsay, SE, Morris RW, Lennon, LT, Peter H Whincup, Sheena E. Ramsay, Ramsay Sheena E., S. G. Wannamethee   +35 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source